Chamazulene

Modify Date: 2024-01-03 08:24:37

Chamazulene structure	Common Name	Chamazulene
	CAS Number	529-05-5	Molecular Weight	184.277
	Density	1.0±0.1 g/cm3	Boiling Point	299.1±20.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆	Melting Point	<25℃
	MSDS	Chinese USA	Flash Point	137.4±12.5 °C

Use of Chamazulene

Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation[1].

Name	Chamazulene
Synonym	More Synonyms

Description	Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
References	[1]. H Safayhi, et al. Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Med. 1994 Oct;60(5):410-3. [2]. Andrea Capuzzo, et al. Antioxidant and radical scavenging activities of chamazulene. Nat Prod Res. 2014;28(24):2321-3. [3]. Ding Ma, et al. Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβpathway in in-vitro and in-vivo models. Biosci Biotechnol Biochem. 2020 Feb;84(2):402-410.

Description

Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation[1].

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

References

[1]. H Safayhi, et al. Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Med. 1994 Oct;60(5):410-3.

[2]. Andrea Capuzzo, et al. Antioxidant and radical scavenging activities of chamazulene. Nat Prod Res. 2014;28(24):2321-3.

[3]. Ding Ma, et al. Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβpathway in in-vitro and in-vivo models. Biosci Biotechnol Biochem. 2020 Feb;84(2):402-410.

Density	1.0±0.1 g/cm3
Boiling Point	299.1±20.0 °C at 760 mmHg
Melting Point	<25℃
Molecular Formula	C₁₄H₁₆
Molecular Weight	184.277
Flash Point	137.4±12.5 °C
Exact Mass	184.125198
LogP	5.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.585
Storage condition	2-8°C

Chamazulene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CO4780000

CHEMICAL NAME :: Azulene, 1,4-dimethyl-7-ethyl-

CAS REGISTRY NUMBER :: 529-05-5

BEILSTEIN REFERENCE NO. :: 1306577

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H16

MOLECULAR WEIGHT :: 184.30

WISWESSER LINE NOTATION :: L57J B1 F1 I2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RRESA8 Rastitel'nye Resursy. Plant Resources. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 3,67,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: RRESA8 Rastitel'nye Resursy. Plant Resources. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 3,67,1967

Hazard Statements	H413
RIDADR	NONH for all modes of transport
HS Code	2902909090

Precursor 7
CAS#:13061-96-6 Methylboronic acid CAS#:68151-26-8 Isodehydrocostu... CAS#:37936-58-6 Azuleno[4,5-b]f... CAS#:93552-70-6 Oxireno[1,2]azu...
CAS#:113807-34-4 artenolide CAS#:2767-14-8 6-Oxo-2.8-dimet... CAS#:101447-99-8 1.4-Dimethyl-7-...
DownStream 0

HS Code	2902909090
Summary	2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation.

Planta Med. 60(5) , 410-3, (1994)

Matricine and its transformation product chamazulene are constituents of chamomile extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since preparations from chamomile ...

[Pharmacologic studies on chamomile compounds. VI. Studies on the antiphlogistic effect of chamazulene and matricine].

Planta Med. 49(2) , 67-73, (1983)

7-Ethyl-1,4-dimethylazulene

Azulene, 7-ethyl-1,4-dimethyl-

Chamazulene

7-Ethyl-1,4-dimethylazulene Chamazulen Dimethulene

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Chamazulene
Price: Click To Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Chamazulene
Price: ￥7058.0/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Chamazulene
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: chamazulene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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