Salinomycin

Suppliers

Names

[ Name ]:
Salinomycin

[Synonym ]:
Coxistac
2H-pyran-2-acetic acid, α-ethyl-6-[(1S,2S,3S,5R)-5-[(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-5-methyl-, (αR,2R,5S,6R)-
Antibiotic 61477
(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid
salinomycin acid
MFCD00036900
SALINOMYCIN SODIUM
Salinomycin
2H-Pyran-2-acetic acid, α-ethyl-6-[(1S,2S,3S,5R)-5-[(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1 .5.3]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-5-methyl-, (αR,2R,5S,6R)-
EINECS 258-290-1
SALINOMYCIN GRANULE
SALINOMYCIN SODIUM SALT
Bio-cox
(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl}-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
839.2±65.0 °C at 760 mmHg

[ Melting Point ]:
112.5-113.5 °C(lit.)

[ Molecular Formula ]:
C₄₂H₇₀O₁₁

[ Molecular Weight ]:
751.00

[ Flash Point ]:
243.2±27.8 °C

[ PSA ]:
164.04000

[ LogP ]:
6.10

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO8620000

CHEMICAL NAME :: Salinomycin

CAS REGISTRY NUMBER :: 53003-10-4

LAST UPDATED :: 198403

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C42-H70-O11

MOLECULAR WEIGHT :: 751.12

WISWESSER LINE NOTATION :: T6XOX DHJ DQ A-& BT6OXTJ C1 E1 FY2&VY1&YQY1&- BT6OTJ C1 FY2&VQ&& C-& BT5OXTJ E1 E- FT6OTJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,813,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1,1978

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300

[ Precautionary Statements ]:
P264-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 3462 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
VO8620000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2309901000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Salinomycin sodium salt
salinomycin acid
D-glucopyranose
(S)-3-((4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl)butanal
(2S,3S,4S)-5-Benzyloxy-2,4-dimethylpentan-1,3-diol
(2S,3R,4S)-1-benzyloxy-3,5-isopropylidenedioxy-2,4-dimethylpentane
(S)-2-[(2R,3S,6R)-6-[(S)-1-(benzyloxymethyl)propyl]-3-methyltetrahydropyran-2-yl]propan-1-ol

DownStream

Customs

[ HS Code ]: 2309901000

Articles

Triggering of erythrocyte cell membrane scrambling by salinomycin.

Basic Clin Pharmacol Toxicol. 115(5) , 396-402, (2015)

Salinomycin, a polyether ionophore antibiotic effective against a variety of pathogens, has been shown to trigger apoptosis of cancer cells and cancer stem cells. The substance is thus considered for ...

High sensitive multiresidue analysis of pharmaceuticals and antifungals in surface water using U-HPLC-Q-Exactive Orbitrap HRMS. Application to the Danube river basin on the Romanian territory.

Sci. Total Environ. 532 , 501-11, (2015)

The occurrence of 67 pharmaceutical and antifungal residues in the Danube river on the Romanian territory was studied by using solid-phase extraction (SPE) and LC-Q Exactive Orbitrap high resolution M...

ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis.

J. Exp. Clin. Cancer Res 34 , 57, (2015)

The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12-14 months. The search for novel and more efficient chemo-agents ag...

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