2-(2-Aminophenyl)ethanol

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Names

[ CAS No. ]:
5339-85-5

[ Name ]:
2-(2-Aminophenyl)ethanol

[Synonym ]:
Phenethyl alcohol, o-amino-
2-Aminophenethyl alcohol
(β-Hydroxyethyl)aniline
MFCD00007754
2-(2-Aminophenyl)ethyl Alcohol
Benzeneethanol, 2-amino-
EINECS 226-275-9
2-(2-Aminophenyl)ethanol
2-(o-aminophenyl)ethanol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
306.7±0.0 °C at 760 mmHg

[ Melting Point ]:
89ºC

[ Molecular Formula ]:
C8H11NO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
127.9±20.4 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
0.08

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.597

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(2-Nitrophenyl)ethanol
  • 2-Nitrotoluene
  • (2-Nitrophenyl)acetic acid
  • 2-(2-nitrophenyl)ethyl nitrate
  • Phenethyl acetate
  • Formaldehyde
  • Water

DownStream

  • 1H-Indole, 1-(dichloroacetyl)-2,3-dihydro- (9CI)
  • Dimethyltryptamine
  • Indoline
  • Indole
  • Benzenamine, 2-ethenyl-
  • 2-(2-Hydroxyethyl)benzonitrile
  • Carbamic acid, N-[2-(2-hydroxyethyl)phenyl]-,1,1-dimethylethyl ester
  • 3-[(4-methoxyphenyl)methyl]-1H-indole
  • Oxindole
  • 2-(2-Iodophenyl)ethan-1-ol

Articles

Ruthenium-catalyzed dehydrogenative N-heterocyclization. Indoles from 2-aminophenethyl alcohols and 2-nitrophenethyl alcohols. Tsuji Y, et al.

J. Org. Chem. 55(2) , 580-84, (1990)

N-(Cyanothioformyl) indoline; a new indoline ring forming reaction. Besson T, et al.

J. Chem. Soc. Perkin Trans. I 24 , 4057-60, (1998)

One-pot cyclization of 2-aminophenethyl alcohols: a novel and direct approach to the synthesis of N-acyl indolines.

J. Org. Chem. 72(24) , 9364-7, (2007)

A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh3, CCl4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields. This ne...


More Articles

Related Compounds

  • 2-[(2-Aminophenyl)-sulfonyl]-ethanol
  • 2-[(2-Aminophenyl)amino]ethanol
  • 2-(2-aminophenyl)-1-propanol
  • 2-[(2-aminophenyl)methyl-methylamino]-1-phenylethanol
  • [2-[(2-Aminophenyl)thio]phenyl][4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]methanone
  • 2-(2-hydroxybutyl)aniline
  • Tert-butyl 5-chloro-6-(ethylamino)pyridine-3-carboxylate
  • (2S)-2-[4-(Trifluoromethyl)pyridin-2-yl]propan-1-amine
  • (2R)-2-Methyl-3-(oxetan-2-yl)propan-1-amine
  • (2S)-4,4,4-Trifluoro-2-methyl-3-phenylbutanoic acid
  • (2S)-2-(1,2,3,4-Tetrahydronaphthalen-1-yl)propanoic acid
  • (2S)-2-(1,2,3,4-Tetrahydronaphthalen-2-yl)propanoic acid
  • 1-(4,4-Difluorocyclohexyl)cyclopropane-1-carboxylic acid
  • (2S)-2-Methyl-3-(1-methylcyclopropyl)propanoic acid
  • 5-Bromo-2-(difluoromethyl)-1-ethoxy-3-fluorobenzene
  • 4-Cyclopropoxy-2-methylpyridine
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