PIT-1

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Names

[ CAS No. ]:
53501-41-0

[ Name ]:
PIT-1

[Synonym ]:
Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide
PIT-1
Impentamine dihydrobromide
N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C14H10ClN3O4S

[ Molecular Weight ]:
351.765

[ Exact Mass ]:
351.008057

[ PSA ]:
139.27000

[ LogP ]:
4.28

[ Index of Refraction ]:
1.747

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010)

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity...

Inhibition of cell migration by PITENINs: the role of ARF6.

Oncogene 31(39) , 4317-32, (2012)

We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activ...


More Articles

Related Compounds

  • DM-PIT-1
  • PIT
  • Propane,1,1-bis(ethylsulfonyl)-2-methyl-
  • Pyridinium, 1- (2-hydroxy[1,1:3,1-terphenyl]-5-yl)-2,4, 6-triphenyl-, perchlorate (salt)
  • Cyclohexanecarboxylicacid, 1-methyl-3-oxo-, ethyl ester
  • 2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 3,5-Bis-benzyloxy-4-(2-methyl-allyl)-benzoic acid tert-butyl ester
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide