PIT-1
PIT-1 structure
|
Common Name | PIT-1 | ||
|---|---|---|---|---|
| CAS Number | 53501-41-0 | Molecular Weight | 351.765 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H10ClN3O4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
Proc. Natl. Acad. Sci. U. S. A. 107(46) , 20126-31, (2010) The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell metabolism, cell survival, and apoptosis. Phosphatidylinositol-3,4,5-trisphosphate (PIP3), the product of PI3K activity and a key signaling molecule, acts by recruiting pleckstri... |
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Inhibition of cell migration by PITENINs: the role of ARF6.
Oncogene 31(39) , 4317-32, (2012) We have reported previously the development of small-molecule phosphatidylinositol-3,4,5-trisphosphate (PIP3) antagonists (PITs) that block pleckstrin homology (PH) domain interaction, including activation of Akt, and show anti-tumor potential. Here we show t... |
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