NP-313

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Names

[ CAS No. ]:
5397-78-4

[ Name ]:
NP-313

[Synonym ]:
2-Acetamido-3-chloro-1,4-naphthoquinone
2-Chloro-3-acetamidonaphthoquinone
2-N-acteylamino-3-chloro-1,4-naphthoquinone
2-acetylamino-3-chloro-1,4-naphthoquinone

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
427.7ºC at 760 mmHg

[ Molecular Formula ]:
C12H8ClNO3

[ Molecular Weight ]:
249.65000

[ Flash Point ]:
212.5ºC

[ Exact Mass ]:
249.01900

[ PSA ]:
63.24000

[ LogP ]:
2.04300

[ Index of Refraction ]:
1.62

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AB7444800
CHEMICAL NAME :
Acetamide, N-(1,4-dihydro-3-chloro-1,4-dioxo-2-naphthyl)-
CAS REGISTRY NUMBER :
5397-78-4
BEILSTEIN REFERENCE NO. :
0524965
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H8-Cl-N-O3
MOLECULAR WEIGHT :
249.66
WISWESSER LINE NOTATION :
L66 BV EVJ CG DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,570,1983

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ACN
  • Ethanoic anhydride
  • Acetyl chloride
  • 2,3-Dichlor-1,4-naphthochinone
  • Acetamide
  • Sulfuric acid

DownStream

  • N-[3-(aziridin-1-yl)-1,4-dioxonaphthalen-2-yl]acetamide
  • N-[3-(methylamino)-1,4-dioxonaphthalen-2-yl]acetamide
  • 5-chloro-3,4-dihydro-2H-benzo[f]quinoxalin-6-one
  • N-(6-oxo-3,4-dihydro-2H-benzo[f]quinoxalin-5-yl)acetamide
  • Naphtho[1',2':4,5]imidazo[1,2-a]pyridine-5,6-dione
  • 1H-Naphth[2,3-d]imidazole-4,9-dione, 2-methyl-1-phenyl-
  • 1H-Naphth[2,3-d]imidazole-4,9-dione
  • N-(5-oxobenzo[a]phenoxazin-6-yl)acetamide
  • N-(10-chloro-5-oxobenzo[a]phenoxazin-6-yl)acetamide
  • N-(9-nitro-5-oxobenzo[a]phenoxazin-6-yl)acetamide

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • NP-G2-044
  • 6-[(1R,5R)-5-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,3-dimethyl-2-oxocyclopentyl]sulfanylhexanoic acid
  • NP-12
  • NP-AHD-13C3
  • CVT-313
  • 2-np-amoz-d5
  • 3-{[(Benzyloxy)carbonyl]amino}-1,2-oxazole-5-carboxylic acid
  • 5-{[(benzyloxy)carbonyl]amino}-1-(2,2,2-trifluoroethyl)-1H-imidazole-4-carboxylic acid
  • 4-{[(tert-butoxy)carbonyl]amino}-1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxylic acid
  • 3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(methoxymethoxy)phenyl]propanoic acid
  • 2-{[(Benzyloxy)carbonyl]amino}-4-butyl-6-fluorobenzoic acid
  • rac-(3aR,7aR)-2-[(benzyloxy)carbonyl]-octahydropyrano[3,4-c]pyrrole-7a-carboxylic acid
  • 2-{[(Benzyloxy)carbonyl]amino}-1-benzothiophene-3-carboxylic acid
  • 1-{1-[(Ethylsulfanyl)methyl]cyclopropyl}methanamine hydrochloride
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (2S)-2-[(methoxycarbonyl)amino]propanoate
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 1-ethyl-1H-imidazole-4-carboxylate
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