NP-313

Modify Date: 2025-08-27 16:52:26

NP-313 structure	Common Name	NP-313
	CAS Number	5397-78-4	Molecular Weight	249.65000
	Density	1.44g/cm3	Boiling Point	427.7ºC at 760 mmHg
	Molecular Formula	C₁₂H₈ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	212.5ºC

Use of NP-313

NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1].

Name	N-(3-chloro-1,4-dioxonaphthalen-2-yl)acetamide
Synonym	More Synonyms

Description	NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca2+ inward flow[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
In Vitro	NP-313 (0-80 μM)可以以剂量依赖的方式抑制血小板的聚集。其中，对凝血酶和 A23187 诱导的血小板聚集，NP-313 的最大抑制程度可分别达到约 80% 和 60%[1]。 NP-313 (0-8 μM) 浓度依赖性地抑制 P-选择素表达以及胶原蛋白或者是凝血酶诱导的人血小板中血栓素 B 2 (TXB2) 生成。同时，NP-313 抑制 COX-1 和 TXA 2合酶的 IC 50 值分别为 1.5 和 3.9 µM[1]。
In Vivo	NP-313 (i.v., 4-16 µg/g)在雄性 ICR 小鼠中显着延长了闭塞时间 (TTO)，延长了出血时间，抑制了由胶原蛋白 (10 µg/mL) 引起的血小板聚集[1]。
References	[1]. Heng-Lan Kuo, et al. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A(2) synthesis and calcium entry. Br J Pharmacol. 2011 Apr;162(8):1871-83.

Density	1.44g/cm3
Boiling Point	427.7ºC at 760 mmHg
Molecular Formula	C₁₂H₈ClNO₃
Molecular Weight	249.65000
Flash Point	212.5ºC
Exact Mass	249.01900
PSA	63.24000
LogP	2.04300
Index of Refraction	1.62
InChIKey	OMXMYDUYAUOFRX-UHFFFAOYSA-N
SMILES	CC(=O)NC1=C(Cl)C(=O)c2ccccc2C1=O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB7444800

CHEMICAL NAME :: Acetamide, N-(1,4-dihydro-3-chloro-1,4-dioxo-2-naphthyl)-

CAS REGISTRY NUMBER :: 5397-78-4

BEILSTEIN REFERENCE NO. :: 0524965

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H8-Cl-N-O3

MOLECULAR WEIGHT :: 249.66

WISWESSER LINE NOTATION :: L66 BV EVJ CG DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,570,1983

HS Code	2924299090

ACN

CAS#:2797-51-5

Ethanoic anhydride

CAS#:108-24-7

~10%

NP-313

CAS#:5397-78-4

Literature: Lien, Jin-Cherng; Wu, Chi-Rei; Hour, Mann-Jen; Huang, Li-Jiau; Huang, Tur-Fu; Kuo, Sheng-Chu Archiv der Pharmazie, 2008 , vol. 341, # 10 p. 639 - 644

ACN

CAS#:2797-51-5

Acetyl chloride

CAS#:75-36-5

~81%

NP-313

CAS#:5397-78-4

Literature: Egleton, James E.; Thinnes, Cyrille C.; Seden, Peter T.; Laurieri, Nicola; Lee, Siu Po; Hadavizadeh, Kate S.; Measures, Angelina R.; Jones, Alan M.; Thompson, Sam; Varney, Amy; Wynne, Graham M.; Ryan, Ali; Sim, Edith; Russell, Angela J. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 3030 - 3054

2,3-Dichlor-1,4...

CAS#:117-80-6

NP-313

CAS#:5397-78-4

Literature: Diaz, Ramiro; Reyes, Oscar; Francois, Angelica; Leiva, Ana Maria; Loeb, Barbara Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6463 - 6467

Acetamide

CAS#:60-35-5

2,3-Dichlor-1,4...

CAS#:117-80-6

NP-313

CAS#:5397-78-4

Literature: Hammam,A.S.; Osman,A.-M. Journal fuer Praktische Chemie (Leipzig), 1977 , vol. 319, p. 254 - 258

Sulfuric acid

CAS#:7664-93-9

ACN

CAS#:2797-51-5

Ethanoic anhydride

CAS#:108-24-7

NP-313

CAS#:5397-78-4

Literature: Fries; Ochwat Chemische Berichte, 1923 , vol. 56, p. 1298

Precursor 6
CAS#:2797-51-5 ACN CAS#:108-24-7 Ethanoic anhydride CAS#:75-36-5 Acetyl chloride CAS#:117-80-6 2,3-Dichlor-1,4...
CAS#:60-35-5 Acetamide CAS#:7664-93-9 Sulfuric acid
DownStream 10
CAS#:100872-64-8 N-[3-(aziridin-... CAS#:1676-56-8 N-[3-(methylami... CAS#:75473-67-5 5-chloro-3,4-di... CAS#:90331-40-1 N-(6-oxo-3,4-di...
CAS#:97339-24-7 Naphtho[1',2':4... CAS#:4497-76-1 1H-Naphth[2,3-d... CAS#:4496-30-4 1H-Naphth[2,3-d... CAS#:58907-74-7 N-(5-oxobenzo[a...
CAS#:58907-75-8 N-(10-chloro-5-... CAS#:58907-77-0 N-(9-nitro-5-ox...

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-Acetamido-3-chloro-1,4-naphthoquinone

2-Chloro-3-acetamidonaphthoquinone

2-N-acteylamino-3-chloro-1,4-naphthoquinone

2-acetylamino-3-chloro-1,4-naphthoquinone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-ACETAMIDO-3-CHLORO-1,4-NAPHTHOQ-
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: NP-313
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.