3,4-Diaminopyridine

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Names

[ CAS No. ]:
54-96-6

[ Name ]:
3,4-Diaminopyridine

[Synonym ]:
3-Pyridinamine, 1,4-dihydro-4-imino-
3,4-Pyridinedramine
3,4-DIAMINOPYRIDINE FOR SYNTHESIS
3,4-Diaminopyridin
3,4-DAP
3,4-diamino-pyridine
3,4-diamino-pyridin
3,4-Diaminopyridine
Amifampridine
3 4-DIAMINOPYRIDINE
Pyridine-3,4-diamine
pyridin-3,4-diaMine
4,5-diaminopyridine
3,4DIAMINOPYRIDINE
EINECS 200-220-9
3,4 DI AMINO PYRIDINE
Pyridin-3,4-diamin
3-amino-4-pyridinylamine
MFCD00006401
3,4-Pyridinediamine
diamino-3,4pyridine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
369.3±22.0 °C at 760 mmHg

[ Melting Point ]:
216-218 °C(lit.)

[ Molecular Formula ]:
C5H7N3

[ Molecular Weight ]:
109.129

[ Flash Point ]:
204.9±9.5 °C

[ Exact Mass ]:
109.063995

[ PSA ]:
64.93000

[ LogP ]:
-0.09

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.676

[ Water Solubility ]:
24 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7600000
CHEMICAL NAME :
Pyridine, 3,4-diamino-
CAS REGISTRY NUMBER :
54-96-6
BEILSTEIN REFERENCE NO. :
0110232
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H7-N3
MOLECULAR WEIGHT :
109.15
WISWESSER LINE NOTATION :
T6NJ CZ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,296,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 150,413,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330-H311-H315-H319-H335

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S37/39-S28A

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
US7600000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Nitropyridin-4-amin
  • 4-Hydrazino-3-nitropyridine
  • 4-benzylamino-3-nitropyridine
  • 4-Hydroxypyridine
  • 4-Ethoxy-3-nitropyridinhydrochlorid
  • 3-Nitro-4-pyridinol
  • 4-AMINOPYRIDINE
  • N-(PYRIDIN-4-YL)ACETAMIDE
  • 4-acetamido-3-nitropyridine

DownStream

  • 1H-Imidazo[4,5-c]pyridin-4-ol
  • 8-Bromo-pyrido[3,4-b]pyrazine
  • 6H-pyrido<3',4':5,6>pyrazino<2,3-b>indole
  • 2-(trifluoromethyl)-1H-imidazo[4,5-c]pyridine
  • 1H-[1,2,3]TRIAZOLO[4,5-C]PYRIDINE
  • Pyrido[3,4-b]pyrazine
  • 2-benzyl-3H-imidazo[4,5-c]pyridine
  • (6E)-6-(1,3-dihydroimidazo[4,5-c]pyridin-2-ylidene)cyclohexa-2,4-dien-1-one
  • 3H-Imidazo[4,5-c]pyridine
  • N3-Benzyl-3,4-pyridinediamine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 4-N-Boc-3,4-diaminopyridine
  • 2-Chloro-3,4-diaminopyridine
  • 2,6-dihydroxy-3,4-diaminopyridine
  • erythro-2-((2-hydroxy-3-nonyl)amino)-3,4-diaminopyridine
  • 3,4-dinitro-2-oxido-1,2,5-oxadiazol-2-ium
  • 3,4-dichlorofuran
  • 1-(3,5-Bis(trifluoromethoxy)phenyl)-3-chloropropan-1-one
  • 1-(2,3-Dichlorophenyl)-8-fluoronaphthalene
  • 1-(2,4-Diformylphenyl)propan-2-one
  • 1-(3-Amino-4-methylphenyl)-3-bromopropan-1-one
  • 1-(3-(Difluoromethoxy)-5-fluorophenyl)propan-2-one
  • 1-(pyridin-2-yl)-4-[(2S)-pyrrolidine-2-carbonyl]piperazine dihydrochloride
  • 4-(Difluoromethyl)-5-methoxy-3-nitropicolinic acid
  • 4-(Difluoromethyl)-5-nitro-3-(trifluoromethoxy)picolinamide
  • 1-(3-Bromopropyl)-2-(difluoromethoxy)-4-nitrobenzene
  • 4-(4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)morpholine
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