3,4-Diaminopyridine
3,4-Diaminopyridine structure
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Common Name | 3,4-Diaminopyridine | ||
|---|---|---|---|---|
| CAS Number | 54-96-6 | Molecular Weight | 109.129 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 369.3±22.0 °C at 760 mmHg | |
| Molecular Formula | C5H7N3 | Melting Point | 216-218 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 204.9±9.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Novel HPLC--Fluorescence methodology for the determination of methylglyoxal and glyoxal. Application to the analysis of monovarietal wines "Ribera del Guadiana".
Food Chem. 187 , 159-65, (2015) The determination and quantification of α-dicarbonyl compounds, glyoxal and methylglyoxal, in "Ribera del Guadiana" monovarietal wines (Extremadura, Spain) without sample clean-up has been carried out by HPLC with spectrofluorimetric detection (307/371 nm). F... |
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Ectopic uterine tissue as a chronic pain generator.
Neuroscience 225 , 269-82, (2012) While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implant... |
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3-D-QSAR and docking studies on the neuronal choline transporter.
Bioorg. Med. Chem. Lett. 20 , 4870-7, (2010) The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug de... |
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Acute and chronic effects of botulinum neurotoxin a on the mammalian neuromuscular junction.
Muscle Nerve 50(2) , 206-15, (2014) Botulinum neurotoxin A (BoNT/A) cleaves SNAP-25 and inhibits acetylcholine (ACh) release at the neuromuscular junctions (NMJ) to cause neuroparalysis. Previous reports indicate a dyssynchrony between the inhibitory effect of BoNT/A on ACh release and SNAP-25 ... |
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Orphan drugs. BioMarin Europe replies.
BMJ 341 , c7006, (2010)
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Open letter to prime minister David Cameron and health secretary Andrew Lansley.
BMJ 341 , c6466, (2010)
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Lack of neuropathy-related phenotypes in hint1 knockout mice.
J. Neuropathol. Exp. Neurol. 73(7) , 693-701, (2014) Mutations in HINT1, the gene encoding histidine triad nucleotide-binding protein 1 (HINT1), cause a recessively inherited peripheral neuropathy that primarily involves motor dysfunction and is usually associated with neuromyotonia (i.e. prolonged muscle contr... |
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Current therapy for Lambert-Eaton myasthenic syndrome: development of 3,4-diaminopyridine phosphate salt as first-line symptomatic treatment.
Curr. Med. Res. Opin. 26(6) , 1363-75, (2010) Lambert-Eaton myasthenic syndrome (LEMS) is a rare pre-synaptic auto-immune disorder of neuromuscular transmission that is characterised by proximal muscle weakness, depressed tendon reflexes and autonomic dysfunction. This review summarises the clinical symp... |
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3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis.
J. Neuroimmunol. 245(1-2) , 75-8, (2012) This study investigated the effect of 3,4-diaminopyridine (3,4-DAP), a potent potentiator of transmitter release, on neuromuscular transmission in vivo in a mouse model of myasthenia gravis (MG) caused by antibodies against muscle-specific kinase (MuSK; MuSK-... |
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Recurrent COLQ mutation in congenital myasthenic syndrome.
Pediatr. Neurol. 46(4) , 253-6, (2012) Congenital myasthenic syndromes comprise clinically and genetically heterogeneous disorders resulting from presynaptic, synaptic, or postsynaptic defects. Mutations in the COLQ gene result in acetylcholinesterase deficiency and cause a rare, autosomal recessi... |