2,5-DICHLOROBENZENESULFONYL CHLORIDE

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Names

[ Name ]:
2,5-DICHLOROBENZENESULFONYL CHLORIDE

[Synonym ]:
Benzenesulfonyl chloride,2,5-dichloro
2,4-DICYANOBENZOTRIFLUORIDE
2,5-Dichlorobenzene-1-sulfonyl chloride
MFCD00007429
2,5-Dichlorobenzenesulfonyl chloride
2,5-dichlorobenzenesulfochloride
2,5-Dichlorobenzenesulphonyl chloride
EINECS 226-453-6
2,5-dichloro-benzenesulfonyl chloride

Chemical & Physical Properties

[ Density]:
1.636 g/cm3

[ Boiling Point ]:
327.6ºC at 760 mmHg

[ Melting Point ]:
36-37 °C(lit.)

[ Molecular Formula ]:
C₆H₃Cl₃O₂S

[ Molecular Weight ]:
245.51100

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
243.89200

[ PSA ]:
42.52000

[ LogP ]:
4.00170

[ Index of Refraction ]:
1.581

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2904909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2,5-dichlorobiphenyl
4,7-dichloro-2-(4,7-dichloro-3-oxobenzo[b]thien-2(3H)-ylidene)benzo[b]thiophene-3(2H)-one
Chlorosulfonic acid
Sulfuric acid
2,5-Dichlorobenzenethiol
2,5-DICHLOROTHIOANISOLE
4-(2,5-dichlorophenyl)sulfonylmorpholine
Benzenesulfonamide,2,5-dichloro-
methyl 2,5-dichlorobenzenesulphonate
2,5-Dichlorobenzenesulfonohydrazide

Customs

[ HS Code ]: 2904909090

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

Bioorg. Med. Chem. Lett. 16 , 1807, (2006)

A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC(50) of 0.57mi...