Etonogestrel

Suppliers

Names

[ CAS No. ]:
54048-10-1

[ Name ]:
Etonogestrel

[Synonym ]:
EINECS 258-936-2
3-Ketodesogestrel,3-Oxodesogestrel,Org-3236,Implanon
Etonoestrel
3-Keto-desogestrel 3-Oxo-desogestrel
(17a)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
3-Oxodesogestrel
3-Keto-Org 2969
18,19-Dinor-17α-pregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-
3-keto-desogestrel
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
13-Ethyl-17-hydroxy-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3-one
3-Ketodesogestrel
Etonogestrel
Nexplanon
Desogestrel Related Compound C (25 mg) (3-Keto-desogestrel)
(8S,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-17-hydroxy-11-methyliden-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-on
UNII-304GTH6RNH
MFCD00867863
Implanon
[3H]-3-keto-Desogestrel
org3236
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)
17-Ethinyl-17b-hydroxy-18-methyl-11-methylene-4-estren-3-one
(8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-11-methylene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
473.1±45.0 °C at 760 mmHg

[ Melting Point ]:
182-184ºC

[ Molecular Formula ]:
C22H28O2

[ Molecular Weight ]:
324.457

[ Flash Point ]:
201.1±21.3 °C

[ Exact Mass ]:
324.208923

[ PSA ]:
37.30000

[ LogP ]:
4.22

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JF8290000
CHEMICAL NAME :
18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)-
CAS REGISTRY NUMBER :
54048-10-1
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C22-H28-O2
MOLECULAR WEIGHT :
324.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10500 ng/kg
SEX/DURATION :
female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 17,19,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
50 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,459,1985

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H351-H360

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
60-40

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
JF8290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • Desogestrel
  • 13-ethyl-gona-4-ene-11α,17β-diol
  • 13-ethyl-11-methylenegon-4-en-17-one
  • 3,3-ethylenedithio-18a-homo-estr-4-ene-11α,17β-diol
  • (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

DownStream

Articles

Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs.

Contraception 90(2) , 123-9, (2014)

The potential effect of hormonal contraception on HIV-1 acquisition and transmission represents an important public health issue. Several observational studies have suggested an association between th...

Newer non-oral hormonal contraception.

BMJ 346 , f341, (2013)

The combined etonogestrel/ethinyl estradiol contraceptive vaginal ring.

Expert Opin. Pharmacother. 8(11) , 1769-77, (2007)

Many factors influence the effectiveness of contraceptive methods. Oral contraceptives are the second most popular contraceptive method after female sterilization in the US. A total of 25% of women do...


More Articles

Related Compounds

  • 18-Demethyl Etonogestrel
  • Etonogestrel and ethinyl estradiol
  • 2-(But-3-yn-1-yl)-1-chloro-3-methylbenzene
  • (1R)-1-(3,4-difluoro-2-methoxyphenyl)-2,2,2-trifluoroethan-1-ol
  • 2-(4-Fluoro-2-methylphenyl)prop-2-enoic acid
  • 2-{1-[2-(Thiophen-3-yl)ethyl]cyclopropyl}propan-2-amine
  • 3-[(5-Bromo-2-methylphenyl)methyl]-3-methoxyazetidine
  • tert-butyl (1S,4R)-5-(3-aminobut-1-en-1-yl)-2-azabicyclo[2.1.1]hexane-2-carboxylate
  • (1R)-1-(3-bromo-5-nitrophenyl)ethan-1-amine
  • tert-butyl N-[4-(1-hydroxycyclopropyl)-3-methoxyphenyl]carbamate
  • 5-(3-Fluorophenyl)-3-methyl-1,2,4-thiadiazole
  • N-(1,6-Dihydro-6-oxo-4-propyl-2-pyrimidinyl)urea
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.