Maleimide

Suppliers

Names

[ CAS No. ]:
541-59-3

[ Name ]:
Maleimide

[Synonym ]:
maleic acid imide
monomaleimide
Maleic imide
EINECS 208-787-4
1H-Pyrrole-2.5-dione
3-pyrroline-2,5-dione
Maleimide
Maleinimide
pyrroline-2,5-dion
2,5-Pyrroledione
1H-Pyrrole-2,5-dione
N-hydroxysuccinimide
MFCD00005494
Pyrrole-2,5-dione

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
264.4±23.0 °C at 760 mmHg

[ Melting Point ]:
91-93 °C(lit.)

[ Molecular Formula ]:
C4H3NO2

[ Molecular Weight ]:
97.072

[ Flash Point ]:
113.7±22.6 °C

[ Exact Mass ]:
97.016380

[ PSA ]:
46.17000

[ LogP ]:
-0.69

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.606

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
SOLUBLE

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON4800000
CHEMICAL NAME :
Maleimide
CAS REGISTRY NUMBER :
541-59-3
BEILSTEIN REFERENCE NO. :
0106910
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C4-H3-N-O2
MOLECULAR WEIGHT :
97.08
WISWESSER LINE NOTATION :
T5VMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 40(11),109,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7766 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - hemorrhage Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - other changes
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 27,151,1978 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
750 ug/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
3100 ug/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H314-H317

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38;R43

[ Safety Phrases ]:
S26-S36/37/39-S45-S37/39-S28A

[ RIDADR ]:
UN 2923 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
ON4800000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29251995

Synthetic Route

Precursor & DownStream

Precursor

  • Maleic anhydride
  • Nickel-acetic acid (1:1)
  • 6-Aminocaproic acid
  • (Z)-4-Amino-4-oxobut-2-enoic acid
  • METHYL 2,5-DIOXO-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE
  • Sulforhodamine 101
  • Hydrochloric acid
  • Bromomaleic anhydride
  • 2,4-Dimethoxybenzylamine
  • Diethyl ether

DownStream

  • (Z)-4-Amino-4-oxobut-2-enoic acid
  • Ethyl 2,5-Dioxopyrrole-1-carboxylate
  • cis-5-Benzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione
  • METHYL 2,5-DIOXO-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXYLATE
  • 3-oxauracil
  • N-(Hydroxymethyl)maleimide
  • 2,3-Naphthalenedicarboximide
  • N-Phenylmaleimide
  • 1-NONYL-PYRROLE-2,5-DIONE
  • PF-06840003

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion.

Nat. Commun. 5 , 5263, (2014)

Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigge...

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.

Antimicrob. Agents Chemother. 59(1) , 193-205, (2014)

Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental and host-mediated challenges. The stress response pathway controlled by the a...

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014)

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melan...


More Articles


Related Compounds

  • maleimide
  • N-Maleimide
  • DNP maleimide
  • F13 Maleimide
  • Maleimide-NOTA
  • Maleimide-DOTA
  • 5:1 Perfluorohexane sulfonate
  • 1-Hydroxy-8:2 fluorotelomer sulfonate
  • 2-Methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide
  • (4S)-2-(4-Bromophenyl)-4-(1-methylethyl)-3-(1-oxopentyl)-5-oxazolidinone
  • 4H-Perfluoropentanesulfonic acid
  • 4:2 FtSOAoS
  • ClOPFLSA n=5
  • 4H-4a,9-Methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (3aS,4aR,5R,7aR,9R,9aR)-
  • PFSMSbtA n=3
  • Hexythiazox metabolite PT-1-4
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.