Maleimide

Modify Date: 2026-06-30 11:00:28

Maleimide Structure
Maleimide structure
 Common Name Maleimide
CAS Number 541-59-3 Molecular Weight 97.072
Density 1.4±0.1 g/cm3 Boiling Point 264.4±23.0 °C at 760 mmHg
Molecular Formula C4H3NO2 Melting Point 91-93 °C(lit.)
MSDS Chinese USA Flash Point 113.7±22.6 °C
Symbol GHS05 GHS06
GHS05, GHS06		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name maleimide
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.4±0.1 g/cm3
Boiling Point 264.4±23.0 °C at 760 mmHg
Melting Point 91-93 °C(lit.)
Molecular Formula C4H3NO2
Molecular Weight 97.072
Flash Point 113.7±22.6 °C
Exact Mass 97.016380
PSA 46.17000
LogP -0.69
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.606
InChIKey PEEHTFAAVSWFBL-UHFFFAOYSA-N
SMILES O=C1C=CC(=O)N1
Storage condition Refrigerator
Water Solubility SOLUBLE

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON4800000
CHEMICAL NAME :
Maleimide
CAS REGISTRY NUMBER :
541-59-3
BEILSTEIN REFERENCE NO. :
0106910
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C4-H3-N-O2
MOLECULAR WEIGHT :
97.08
WISWESSER LINE NOTATION :
T5VMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 40(11),109,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7766 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - hemorrhage Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - other changes
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 27,151,1978 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
750 ug/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
3100 ug/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger
Hazard Statements H301-H314-H317
Precautionary Statements P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R25;R36/37/38;R43
Safety Phrases S26-S36/37/39-S45-S37/39-S28A
RIDADR UN 2923 8/PG 2
WGK Germany 3
RTECS ON4800000
Packaging Group III
Hazard Class 8
HS Code 29251995

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles174

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion.

Nat. Commun. 5 , 5263, (2014)

Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigge...

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.

Antimicrob. Agents Chemother. 59(1) , 193-205, (2014)

Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental and host-mediated challenges. The stress response pathway controlled by the a...

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014)

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melan...

 MaleimideBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Kinase Inhibition Assay from Article 10.1021/jm040895g: "SAR and 3D-QSAR studies on t...
Source: BindingDB
Target: N/A
External Id: BindingDB_987_1
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Total 291, Current Page 1 of 30
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

maleic acid imide
monomaleimide
Maleic imide
EINECS 208-787-4
1H-Pyrrole-2.5-dione
3-pyrroline-2,5-dione
Maleimide
Maleinimide
pyrroline-2,5-dion
2,5-Pyrroledione
1H-Pyrrole-2,5-dione
N-hydroxysuccinimide
MFCD00005494
Pyrrole-2,5-dione

 Maleimide | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of maleimide?
A: CAS number of maleimide is 541-59-3.
Q: What is the molecular weight of maleimide?
A: Molecular weight of maleimide is 97.072.
Q: What is the polar surface area (PSA) of maleimide?
A: Polar surface area (PSA) of maleimide is 46.17000.
Q: What is the safety information for maleimide?
A: Safety information for maleimide: S26-S36/37/39-S45-S37/39-S28A.
Q: What is the LogP of maleimide?
A: LogP of maleimide is -0.69.
Q: How is the water solubility of maleimide?
A: Water solubility of maleimide: SOLUBLE.
Q: What is the melting point of maleimide?
A: Melting point of maleimide is 91-93 °C(lit.).
Q: What is the boiling point of maleimide?
A: Boiling point of maleimide is 264.4±23.0 °C at 760 mmHg.
Q: What are the downstream products of maleimide?
A: Related downstream products(CAS) of maleimide: 557-24-4;55750-49-7;370879-53-1;55750-48-6;34314-63-1;5063-96-7;4379-54-8;941-69-5;20458-51-9;198474-05-4.
Q: What is the InChIKey of maleimide?
A: InChIKey of maleimide is PEEHTFAAVSWFBL-UHFFFAOYSA-N.

 Maleimidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides Maleimide(CAS#:541-59-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Maleimide are included as well.>> amp version: Maleimide

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