9H-Purine,6-(ethylthio)-

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Names

[ CAS No. ]:
5417-84-5

[ Name ]:
9H-Purine,6-(ethylthio)-

[Synonym ]:
6-Ethylmercaptopurine
QA 69
6-ETHYLTHIOPURINE
6-Ethyl MP

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Boiling Point ]:
460.2ºC at 760mmHg

[ Molecular Formula ]:
C7H8N4S

[ Molecular Weight ]:
180.23000

[ Flash Point ]:
232.1ºC

[ Exact Mass ]:
180.04700

[ PSA ]:
79.76000

[ LogP ]:
1.46490

[ Index of Refraction ]:
1.758

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO8535000
CHEMICAL NAME :
Purine, 6-(ethylthio)-
CAS REGISTRY NUMBER :
5417-84-5
LAST UPDATED :
198502
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H8-N4-S
MOLECULAR WEIGHT :
180.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
164 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 71,618,1982

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
UO8535000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bromoethane
  • 6-Mercaptopurine
  • Ethyl iodide
  • 6-chloropurine
  • Ethanethiol

DownStream

  • 6-ethylsulfonyl-7H-purine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation.

Oncogene 9(5) , 1407-16, (1994)

Overexpression of v-ski blocks the terminal differentiation of chicken erythroblasts, and in cooperation with v-sea causes transformation of these cells, indicating that c-ski may play a role in regul...

6-ethylmercaptopurine-mediated growth inhibition of HL-60 cells in vitro irrespective of purine salvage.

Cancer Chemother. Pharmacol. 25(3) , 189-94, (1989)

A variety of purine analogs inhibit the growth and induce the differentiation of human promyelocytic leukemia (HL-60) cells that lack the purine salvage enzyme hypoxanthine-guanine phosphoribosyltrans...

Differential effect of 6-ethylmercaptopurine on c-myc expression in wild-type and HGPRT-deficient HL-60 cells.

Cancer Chemother. Pharmacol. 27(3) , 171-7, (1990)

A variety of compounds inhibit the growth and induce differentiation of human promyelocytic leukemia (HL-60) cells. HL-60 subclones that lack the purine salvage enzyme hypoxanthine-guanine phosphoribo...


More Articles

Related Compounds

  • 9H-Purine,6-[(ethylthio)methyl]-
  • 9H-Purine-6-thiol, 9-[D-gluco-1-(ethylthio)-2,3,4,5, 6-pentahydroxyhexyl]-
  • 9H-Purine-9-methanol,6-(ethylthio)-
  • 9H-Purine-6 (1H)-thione, 9-amino-
  • 9H-Purine, 6-iodo-9- (tetrahydro-9-furanyl)-
  • 9H-Purine,6-(hexylthio)-