Albendazole

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Names

[ Name ]:
Albendazole

[Synonym ]:
Carbamic acid, N-[5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
Methyl hydrogen [6-(propylsulfanyl)-1H-benzimidazol-2-yl]carbonimidate
SKF62979
Methanol, 1-methoxy-1-[[6-(propylthio)-1H-benzimidazol-2-yl]imino]-, (E)-
Bilutac
MFCD00083232
ALBEN
Atasol
carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
SK&F-62979
ZENTEL
SK&F 62979
ALBENZA
EINECS 259-414-7
methyl-5-propylthio-2-benzimidazole carbamate
Bruzol
methyl N-[5-(propylthio)-1H-benzimidazol-2-yl]carbamate
Albendazole
ZEBEN
methyl [5-(propylthio)-1H-benzimidazol-2-yl]carbamate
methyl 5-(propylthio)benzimidazol-2-ylcarbamate
5-propylthio-2-carbomethoxyaminobenzimidazole
Methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate
methyl [5-(propylsulfanyl)-1H-1,3-benzimidazol-2-yl]carbamate
Monil
SK&F62979

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
207-211°C（分解）

[ Molecular Formula ]:
C₁₂H₁₅N₃O₂S

[ Molecular Weight ]:
265.331

[ Exact Mass ]:
265.088501

[ PSA ]:
92.31000

[ LogP ]:
3.07

[ Index of Refraction ]:
1.634

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD1100000

CHEMICAL NAME :: Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester

CAS REGISTRY NUMBER :: 54965-21-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H15-N3-O2-S

MOLECULAR WEIGHT :: 265.36

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GS3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 71 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 85 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,185,1995

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361-H373

[ Precautionary Statements ]:
P281

[ Target Organs ]:
Blood

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R61:May cause harm to the unborn child. R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S53-S45-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
FD1100000

[ HS Code ]:
3004909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Carbamic acid,N-cyano-, methyl ester
4-(Propylsulfanyl)-1,2-benzenediamine
2-[(methoxycarbonyl)-amino]-1H-benzimidazole-5-sulphonylchloride hydrochloride salt
Cyanamide
Methyl chloroformate
2-Nitroaniline
2-Nitro-4-thiocyanatoaniline
2-Nitro-4-(propylthio)aniline
1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudoeura
5-propylsulfanylspiro[1,3-dihydrobenzimidazole-2,1'-cyclohexane]

DownStream

Customs

[ HS Code ]: 2933990013

[ Summary ]:
2933990013 6-(3,5-dichloro-4-methylphenyl)pyridazin-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

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