Albendazole

Modify Date: 2024-01-02 16:05:41

Albendazole structure	Common Name	Albendazole
	CAS Number	54965-21-8	Molecular Weight	265.331
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₅N₃O₂S	Melting Point	207-211°C（分解）
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Warning

Use of Albendazole

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.Target: AntiparasiticAlbendazole, marketed as Albenza (United States), Eskazole, Zentel, Andazol and Alworm, is a benzimidazole drug used for the treatment of a variety of parasitic worm infestations. Although this use is widespread in the United States, the U.S. Food and Drug Administration (FDA) has not approved albendazole for this indication. It is marketed by Amedra Pharmaceuticals. Albendazole was first discovered at the SmithKline Animal Health Laboratories in 1972. It is a broad spectrum anthelmintic, effective against roundworms, tapeworms, and flukes of domestic animals and humans.Albendazole has been used as an anthelmintic and for control of flukes in a variety of animal species, including cattle, sheep, goats, swine, camels, dogs, cats, elephants, poultry and others. In many countries, it is very commonly used for ruminant livestock. For use in livestock, albendazole is marketed by Zoetis (formerly Pfizer Animal Health) in numerous countries (including the United States and Canada) as Valbazen in oral suspension and paste formulations; by Interchemie in the Netherlands and elsewhere as Albenol-100; by Channelle Animal Health Ltd. in the United Kingdom as Albex; by Ravensdown in New Zealand as Albendazole; etc. Although most formulations are administered orally, Ricomax (ricobendazole, or albendazole sulfoxide) is administered by subcutaneous injection.

Name	albendazole
Synonym	More Synonyms

Description	Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.Target: AntiparasiticAlbendazole, marketed as Albenza (United States), Eskazole, Zentel, Andazol and Alworm, is a benzimidazole drug used for the treatment of a variety of parasitic worm infestations. Although this use is widespread in the United States, the U.S. Food and Drug Administration (FDA) has not approved albendazole for this indication. It is marketed by Amedra Pharmaceuticals. Albendazole was first discovered at the SmithKline Animal Health Laboratories in 1972. It is a broad spectrum anthelmintic, effective against roundworms, tapeworms, and flukes of domestic animals and humans.Albendazole has been used as an anthelmintic and for control of flukes in a variety of animal species, including cattle, sheep, goats, swine, camels, dogs, cats, elephants, poultry and others. In many countries, it is very commonly used for ruminant livestock. For use in livestock, albendazole is marketed by Zoetis (formerly Pfizer Animal Health) in numerous countries (including the United States and Canada) as Valbazen in oral suspension and paste formulations; by Interchemie in the Netherlands and elsewhere as Albenol-100; by Channelle Animal Health Ltd. in the United Kingdom as Albex; by Ravensdown in New Zealand as Albendazole; etc. Although most formulations are administered orally, Ricomax (ricobendazole, or albendazole sulfoxide) is administered by subcutaneous injection.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Theodorides VJ, et al. Anthelmintic activity of albendazole against liver flukes, tapeworms., lung and gastrointestinal roundworms. Experientia. 1976 Jun 15;32(6):702-3.

Density	1.3±0.1 g/cm3
Melting Point	207-211°C（分解）
Molecular Formula	C₁₂H₁₅N₃O₂S
Molecular Weight	265.331
Exact Mass	265.088501
PSA	92.31000
LogP	3.07
Index of Refraction	1.634
Storage condition	0-6°C

Albendazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD1100000

CHEMICAL NAME :: Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester

CAS REGISTRY NUMBER :: 54965-21-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H15-N3-O2-S

MOLECULAR WEIGHT :: 265.36

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GS3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 71 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 85 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,185,1995

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361-H373
Precautionary Statements	P281
Target Organs	Blood
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T
Risk Phrases	R61:May cause harm to the unborn child. R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S53-S45-S37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	FD1100000
HS Code	3004909090

Carbamic acid,N...

CAS#:21729-98-6

4-(Propylsulfan...

CAS#:66608-52-4

Albendazole

CAS#:54965-21-8

Literature: SEQUENT SCIENTIFIC LIMITED; Rane, Ramkrishna Appaji; Naithani, Sushil; Natikar, Rajendra Devendra; Verma, Sudhakar; Arulmoli, Thangavel Patent: US2013/303782 A1, 2013 ; Location in patent: Paragraph 0031 ;

2-[(methoxycarb...

CAS#:105530-56-1

Albendazole

CAS#:54965-21-8

Literature: US4368328 A1, ;

Cyanamide

CAS#:420-04-2

4-(Propylsulfan...

CAS#:66608-52-4

Methyl chloroformate

CAS#:79-22-1

~30%

Albendazole

CAS#:54965-21-8

Literature: Hazelton; Iddon; Suschitzky; Woolley Tetrahedron, 1995 , vol. 51, # 39 p. 10771 - 10794

2-Nitroaniline

CAS#:88-74-4

Albendazole

CAS#:54965-21-8

Literature: WO2012/70069 A2, ;

2-Nitro-4-thioc...

CAS#:54029-45-7

Albendazole

CAS#:54965-21-8

Literature: WO2012/70069 A2, ;

2-Nitro-4-(prop...

CAS#:54393-89-4

Albendazole

CAS#:54965-21-8

Literature: WO2012/70069 A2, ;

1,3-Bis(methoxy...

CAS#:34840-23-8

4-(Propylsulfan...

CAS#:66608-52-4

~43%

Albendazole

CAS#:54965-21-8

Literature: Hazelton; Iddon; Suschitzky; Woolley Tetrahedron, 1995 , vol. 51, # 39 p. 10771 - 10794

1,3-Bis(methoxy...

CAS#:34840-23-8

5-propylsulfany...

CAS#:141421-17-2

~29%

Albendazole

CAS#:54965-21-8

Literature: Hazelton; Iddon; Suschitzky; Woolley Tetrahedron, 1995 , vol. 51, # 39 p. 10771 - 10794

methyl 1-[(4-am...

CAS#:740075-69-8

Albendazole

CAS#:54965-21-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1359 - 1362

Precursor 10
CAS#:21729-98-6 Carbamic acid,N... CAS#:66608-52-4 4-(Propylsulfan... CAS#:105530-56-1 2-[(methoxycarb... CAS#:420-04-2 Cyanamide
CAS#:79-22-1 Methyl chloroformate CAS#:88-74-4 2-Nitroaniline CAS#:54029-45-7 2-Nitro-4-thioc... CAS#:54393-89-4 2-Nitro-4-(prop...
CAS#:34840-23-8 1,3-Bis(methoxy... CAS#:141421-17-2 5-propylsulfany...
DownStream 2
CAS#:80983-36-4 Amino Albendazole CAS#:54029-12-8 Albendazole Oxide

HS Code	2933990013
Summary	2933990013 6-(3,5-dichloro-4-methylphenyl)pyridazin-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

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Carbamic acid, N-[5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester

Methyl hydrogen [6-(propylsulfanyl)-1H-benzimidazol-2-yl]carbonimidate

SKF62979

Methanol, 1-methoxy-1-[[6-(propylthio)-1H-benzimidazol-2-yl]imino]-, (E)-

Bilutac

MFCD00083232

ALBEN

Atasol

carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester

SK&F-62979

ZENTEL

SK&F 62979

ALBENZA

EINECS 259-414-7

methyl-5-propylthio-2-benzimidazole carbamate

Bruzol

methyl N-[5-(propylthio)-1H-benzimidazol-2-yl]carbamate

Albendazole

ZEBEN

methyl [5-(propylthio)-1H-benzimidazol-2-yl]carbamate

methyl 5-(propylthio)benzimidazol-2-ylcarbamate

5-propylthio-2-carbomethoxyaminobenzimidazole

Methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate

methyl [5-(propylsulfanyl)-1H-1,3-benzimidazol-2-yl]carbamate

Monil

SK&F62979

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Albendazole
Price: ￥78.0/5g ￥278.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Albendazole(Albenza)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Albendazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Albendazole
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: ALBENDAZOLE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Albendazole

Use of Albendazole

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Albendazole Biological Activity

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