4-Methoxyphenylethylamine

Names

[ CAS No. ]:
55-81-2

[ Name ]:
4-Methoxyphenylethylamine

[Synonym ]:
4-Methoxyphenethylamine
MFCD00008192
EINECS 200-245-5
4-Methoxyphenylethylamine
2-(4-Methoxyphenyl)ethanamine
4-Methoxy-β-phenylethylamine
Benzeneethanamine, 4-methoxy-

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
255.2±0.0 °C at 760 mmHg

[ Melting Point ]:
249-251°C

[ Molecular Formula ]:
C₉H₁₃NO

[ Molecular Weight ]:
151.206

[ Flash Point ]:
105.3±13.6 °C

[ Exact Mass ]:
151.099716

[ PSA ]:
35.25000

[ LogP ]:
1.37

[ Appearance of Characters ]:
liquid | light yellow

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.526

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH7875000

CHEMICAL NAME :: Phenethylamine, p-methoxy-

CAS REGISTRY NUMBER :: 55-81-2

BEILSTEIN REFERENCE NO. :: 0508967

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H13-N-O

MOLECULAR WEIGHT :: 151.23

WISWESSER LINE NOTATION :: Z2R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7150 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SH7875000

[ HS Code ]:
29222900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-(4-Methoxyphenyl)-2-nitroethylene
(4-Methoxyphenyl)acetonitrile
3-(4-METHOXYPHENYL)PROPIONAMIDE
1-methoxy-4-(2-nitroethyl)benzene
1-(2-azidoethyl)-4-methoxy-benzene
2,2,2-trichloroethyl 4-methoxyphenethylcarbamate
1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol
methyl N-[2-(4-methoxyphenyl)ethyl]carbamate
2-(4-Methoxyphenyl)ethanol

DownStream

N-Methyltyramine
phenethylamine, p-methoxy-n-methyl-
Benzamide
5-chloro-2-methoxy-N-(2-(4-methoxyphenyl)ethyl)benzamide
(4,4-DIFLUOROCYCLOHEXYL)ACETICACID
Methanol
2-Cyclohexylethylamine
Tyramine
1-(2-HYDROXYPHENYL)PIPERAZINEDIHYDROBROMIDE
Hordenine methiodide

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis.

Biochemistry 40 , 14215, (2001)

Cytochrome P450 (P450) 2D6 oxidizes a wide variety of drugs typically at a distance of 5-7 A from a basic nitrogen on the substrate. To investigate the determinants of P450 2D6 catalysis, we analyzed ...

Electrochemical Investigation of oligonucleotide-DNA hybridization on poly(4-methoxyphenethylamine).

Int. J. Mol. Sci. 9(7) , 1173-88, (2008)

This work describes the immobilization of purine and pyrimidine bases and immobilization/hybridization of synthetic oligonucleotides on graphite electrodes modified with poly(4-methoxyphenethylamine) ...

Selectivity of 4-methoxyphenethylamine derivatives as inhibitors of monoamine oxidase.

J. Pharm. Sci. 65(10) , 1539-40, (1976)

It has been established that the oxidative deamination of tyramine by monoamine xodase is inhibited by (+/-)-4-methoxy-beta-hydroxyphenethylamine and its N-methylated derivatives. This particular seri...