4-Methoxyphenylethylamine
4-Methoxyphenylethylamine structure
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Common Name | 4-Methoxyphenylethylamine | ||
|---|---|---|---|---|
| CAS Number | 55-81-2 | Molecular Weight | 151.206 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 255.2±0.0 °C at 760 mmHg | |
| Molecular Formula | C9H13NO | Melting Point | 249-251°C | |
| MSDS | Chinese USA | Flash Point | 105.3±13.6 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis.
Biochemistry 40 , 14215, (2001) Cytochrome P450 (P450) 2D6 oxidizes a wide variety of drugs typically at a distance of 5-7 A from a basic nitrogen on the substrate. To investigate the determinants of P450 2D6 catalysis, we analyzed the binding and oxidation of phenethylamine substrates. P45... |
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Electrochemical Investigation of oligonucleotide-DNA hybridization on poly(4-methoxyphenethylamine).
Int. J. Mol. Sci. 9(7) , 1173-88, (2008) This work describes the immobilization of purine and pyrimidine bases and immobilization/hybridization of synthetic oligonucleotides on graphite electrodes modified with poly(4-methoxyphenethylamine) produced in acid medium. The immobilization of adenine, gua... |
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Selectivity of 4-methoxyphenethylamine derivatives as inhibitors of monoamine oxidase.
J. Pharm. Sci. 65(10) , 1539-40, (1976) It has been established that the oxidative deamination of tyramine by monoamine xodase is inhibited by (+/-)-4-methoxy-beta-hydroxyphenethylamine and its N-methylated derivatives. This particular series of compounds does not inhibit the action of monoamine ox... |
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Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
Biochemistry 42(5) , 1245-53, (2003) Human cytochrome P450 (P450) 2D6 is an important enzyme involved in the metabolism of drugs, many of which are amines or contain other basic nitrogen atoms. Asp301 has generally been considered to be involved in electrostatic docking with the basic substrates... |
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[An increase in the radioprotective effect of O-methyltyramine and mezaton by monoamine oxidase inhibitors].
Radiobiologiia 33(1) , 137-40, (1993) Specific 2-propynylamine inhibitors of monoamine oxidase (MAO) pargyline and especially chlorgyline, a selective inhibitor of MAO A (but not deprenyl, a selective inhibitor of MAO B) increase the radioprotective effect of small doses of O-methyltyramine and p... |
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Next generation techniques in the high resolution spectroscopy of biologically relevant molecules.
Phys. Chem. Chem. Phys. 13(16) , 7253-62, (2011) Recent advances in the technology of test and measurement equipment driven by the computer and telecommunications industries have made possible the development of a new broadband, Fourier-transform microwave spectrometer that operates on principles similar to... |
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Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.
J. Biol. Chem. 277(37) , 33711-9, (2002) Cytochrome P450 (P450) 2D6 is involved in the oxidation of a large fraction ( approximately 30%) of drugs used by humans and also catalyzes the O-demethylation of the model substrates 3- and 4-methoxyphenethylamine followed by subsequent ring hydroxylation to... |
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Comparative effects of various serotonin releasing agents in mice.
Biochem. Pharmacol. 29(23) , 3163-7, (1980)
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The K+ liquid ion exchange electrode system: responses to drugs and neurotransmitters.
J. Neurosci. Res. 6(1) , 37-48, (1981) K+-sensitive liquid ion exchange electrode systems respond with a slow potential change to acetylcholine, choline, anticholinergic drugs, biogenic amines, and glutamic acid. The response threshold has been defined, and in most cases it is at extremely low con... |
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Chiral discrimination and interaction mechanism between enantiomers and serum albumins.
J. Mol. Recognit. 26(4) , 161-4, (2013) The chiral discrimination studies of biological system are theoretically and practically significant for the development of chiral drugs and life science. Our work has embarked upon the interaction between serum albumin (SA) (including human SA and bovine SA)... |