Paeonol

Suppliers

Names

[ CAS No. ]:
552-41-0

[ Name ]:
Paeonol

[Synonym ]:
1-(2-Hydroxy-4-methoxyphenyl)ethanone
2-Acetyl-5-methoxy-phenol
2-Hydroxy-4-methoxyacetophenone
EINECS 209-012-2
Acetophenone, 2'-hydroxy-4'-methoxy-
Ethanone, 1- (2-hydroxy-4-methoxyphenyl)-
2'-hydroxy-4'-methoxyacetophenone
4-Methoxy-2-hydroxyacetophenone
Paeonol
MFCD00008730
Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-
1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
301.9±22.0 °C at 760 mmHg

[ Melting Point ]:
48-50 °C(lit.)

[ Molecular Formula ]:
C₉H₁₀O₃

[ Molecular Weight ]:
166.174

[ Flash Point ]:
122.3±15.8 °C

[ Exact Mass ]:
166.062988

[ PSA ]:
46.53000

[ LogP ]:
2.16

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.538

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT1215000

CHEMICAL NAME :: Paeonol

CAS REGISTRY NUMBER :: 552-41-0

BEILSTEIN REFERENCE NO. :: 1282794

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 49,84,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 781 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1205,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 196 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,1205,1969

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S28-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RT1215000

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,4-Dihydroxyacetophenone
Dimethyl sulfate
methyl iodide
Phenol, 3-methoxy-,1-acetate
1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethanone
2',4'-dimethoxyacetophenone
m-Methoxyphenol
Acetyl chloride
acetic acid

DownStream

2-Propen-1-one,3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-
2,5-Dihydroxyacetophenone
4-Chromanone
7-Methoxychroman-4-one
2-(4-chlorophenyl)-7-hydroxychromen-4-one
2,5-Dihydroxy-4-methoxyacetophenone
2',3'-Dihydroxy-4'-methoxyacetophenone
2,2-DIMETHYL-7-METHOXY-4-CHROMANONE
4'-O-Methylbroussochalcone B
2,4-Dihydroxyacetophenone

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Competitive molecular interaction among paeonol-loaded liposomes: differential scanning calorimetry and synchrotron X-ray diffraction studies.

Int. J. Pharm. 438(1-2) , 91-7, (2012)

Thermotropic phase behavior of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes containing 5 mol% cholesterol, or 5 mol% stigmasterol, or 5 mol% paeonol have been investigated by different...

Paeonol inhibits oxidized low density lipoprotein-induced monocyte adhesion to vascular endothelial cells by inhibiting the mitogen activated protein kinase pathway.

Biol. Pharm. Bull. 35(5) , 767-72, (2012)

Atherosclerosis is a chronic inflammatory disease characterized by increased expression of adhesion molecules, which contribute to monocytes adhesion to vascular endothelial cells (VECs). Paeonol, an ...

Influence of co-administered danshensu on pharmacokinetic fate and tissue distribution of paeonol in rats.

Planta Med. 78(2) , 135-40, (2012)

Cortex Moutan (root bark of Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae (root and rhizome of Salvia miltiorrhiza Bunge) are two herbs widely used in traditional Chinese medicine (TCM)...