Nicotinohydrazide

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Names

[ CAS No. ]:
553-53-7

[ Name ]:
Nicotinohydrazide

[Synonym ]:
Nicotinohydrazide
pyridine-3-carbohydrazide
EINECS 209-041-0
MFCD00006383
3-Pyridinecarboxylic acid, hydrazide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
159-161 °C(lit.)

[ Molecular Formula ]:
C6H7N3O

[ Molecular Weight ]:
137.139

[ Exact Mass ]:
137.058914

[ PSA ]:
68.01000

[ LogP ]:
-0.83

[ Index of Refraction ]:
1.584

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT1750000
CHEMICAL NAME :
Nicotinic acid, hydrazide
CAS REGISTRY NUMBER :
553-53-7
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H7-N3-O
MOLECULAR WEIGHT :
137.16
WISWESSER LINE NOTATION :
T6NJ CVMZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04178
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,691,1955 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
124 gm/kg/71W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 38,106,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S22-S26-S36/37/39

[ RIDADR ]:
UN2811

[ WGK Germany ]:
3

[ RTECS ]:
QT1750000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl nicotinate
  • Ethyl nicotinate
  • Nicotinic acid
  • Nicotinamide
  • Nicotinoyl chloride
  • N'-(1-((2S,4S)-4-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylidene)nicotinohydrazide hydrochloride

DownStream

  • 6-chloro-3-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazine
  • 5-(Pyridin-3-yl)-4H-1,2,4-triazol-3-amine
  • Nicotinaldehyde
  • 3-[5-[(4-methylphenoxy)methyl]-4-(4-methylphenyl)-1,2,4-triazol-3-yl]pyridine
  • 3-[5-[(4-chloro-3-methylphenoxy)methyl]-4-(4-methylphenyl)-1,2,4-triazol-3-yl]pyridine
  • 5-(Pyridin-3-yl)-1,3,4-oxadiazole-2-thiol
  • 2-phenoxypyridine-3-carbonyl chloride
  • 3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridine
  • 3-Pyridinecarboxylicacid, 2-[(4-hydroxy-3-methoxyphenyl)methylene]hydrazide
  • Nicotinic acid

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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Colloids Surf. B Biointerfaces 125 , 151-9, (2015)

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Proc. Natl. Acad. Sci. U. S. A. 98(4) , 1347-52, (2001)

Dynamic combinatorial libraries are mixtures of compounds that exist in a dynamic equilibrium and can be driven to compositional self adaptation via selective binding of a specific assembly of certain...


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Related Compounds

  • Nicotinohydrazide 1-oxide
  • 6-(TRIFLUOROMETHYL)NICOTINOHYDRAZIDE
  • N'-benzenesulfono-N-nicotinohydrazide
  • N'-(1-Methylethylidene)nicotinohydrazide
  • N'-(2-Pyridylmethylene)nicotinohydrazide
  • 2-METHYL-6-(TRIFLUOROMETHYL)NICOTINOHYDRAZIDE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine