Nicotinohydrazide

Modify Date: 2025-08-22 10:49:38

Nicotinohydrazide Structure
Nicotinohydrazide structure
Common Name Nicotinohydrazide
CAS Number 553-53-7 Molecular Weight 137.139
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C6H7N3O Melting Point 159-161 °C(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Nicotinohydrazide


Nicotinohydrazide (Nicotinic acid hydrazide) is a small molecular compound[1].

 Names

Name Nicotinohydrazide
Synonym More Synonyms

 Nicotinohydrazide Biological Activity

Description Nicotinohydrazide (Nicotinic acid hydrazide) is a small molecular compound[1].
Related Catalog
References

[1]. Kruszynski R. A structural and theoretical study of intermolecular interactions in nicotinohydrazide dihydrochloride. Acta Crystallogr C. 2011 Feb;67(Pt 2):o52-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Melting Point 159-161 °C(lit.)
Molecular Formula C6H7N3O
Molecular Weight 137.139
Exact Mass 137.058914
PSA 68.01000
LogP -0.83
Index of Refraction 1.584
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT1750000
CHEMICAL NAME :
Nicotinic acid, hydrazide
CAS REGISTRY NUMBER :
553-53-7
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H7-N3-O
MOLECULAR WEIGHT :
137.16
WISWESSER LINE NOTATION :
T6NJ CVMZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04178
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,691,1955 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
124 gm/kg/71W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 38,106,1981

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R40
Safety Phrases S22-S26-S36/37/39
RIDADR UN2811
WGK Germany 3
RTECS QT1750000
Packaging Group III
Hazard Class 6.1
HS Code 2933399090

 Synthetic Route

~98%

Nicotinohydrazide Structure

Nicotinohydrazide

CAS#:553-53-7

Literature: Khan, Khalid Mohammad; Rasheed, Maimona; Ullah, Zia; Hayat, Safdar; Kaukab, Farhana; Choudhary, M. Iqbal; Ur-Rahman, Atta; Perveen, Shahnaz Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1381 - 1387

~82%

Nicotinohydrazide Structure

Nicotinohydrazide

CAS#:553-53-7

Literature: Zou, Liang-Hua; Reball, Jens; Mottweiler, Jakob; Bolm, Carsten Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 92 p. 11307 - 11309,3

~94%

Nicotinohydrazide Structure

Nicotinohydrazide

CAS#:553-53-7

Literature: Elshaarawy, Reda F.M.; Janiakb, Christoph Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2011 , vol. 66, # 12 p. 1202 - 1208

~85%

Nicotinohydrazide Structure

Nicotinohydrazide

CAS#:553-53-7

Literature: Hassan, Heba A.; Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.A.; Farag, Hassan H. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 4 p. 1681 - 1692

~%

Nicotinohydrazide Structure

Nicotinohydrazide

CAS#:553-53-7

Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 52, # 10 p. 1318 - 1324

~%

Nicotinohydrazide Structure

Nicotinohydrazide

CAS#:553-53-7

Literature: Pharmaceutical Chemistry Journal, , vol. 21, # 6 p. 398 - 402 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 6 p. 663 - 667

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

Nicotinohydrazide
pyridine-3-carbohydrazide
EINECS 209-041-0
MFCD00006383
3-Pyridinecarboxylic acid, hydrazide
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