Prostaglandin F2α 1,15-lactone (PGF2α 1,15-lactone)

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Names

[ CAS No. ]:
55314-49-3

[ Name ]:
Prostaglandin F2α 1,15-lactone (PGF2α 1,15-lactone)

[Synonym ]:
pgf2-alpha1,15-lactone
Prosta-5,13-dien-1-one, 1,15-epoxy-9,11-dihydroxy-, (5Z,9α,11α,13E,15S)-
(5Z,9α,11α,13E,15S)-9,11-Dihydroxy-1,15-epoxyprosta-5,13-dien-1-one
13e,15s)-1-alph
PROSTAGLANDIN F2ALPHA 1,15-LACTONE

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
524.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H32O4

[ Molecular Weight ]:
336.466

[ Flash Point ]:
180.9±23.6 °C

[ Exact Mass ]:
336.230072

[ PSA ]:
66.76000

[ LogP ]:
3.09

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.503

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8020600
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, lambda-lactone, (5Z,9-alpha,11-alpha, 13E,15S)-
CAS REGISTRY NUMBER :
55314-49-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H32-O4
MOLECULAR WEIGHT :
336.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
4 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 14,477,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
800 ug/kg
SEX/DURATION :
female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1089,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (1S,5R,5aR,6E,8S,14Z,16aR)-3-butyl-8-pentyl-1,5a,8,11,12,13,16,16a-octahydro-5H,10H-1,5-methano[1,3,2]dioxaborepino[5,6-e][1]oxacyclotridecin-10-one

DownStream

  • PGE2-1,15-lactone

Related Compounds

  • 1-methyl-1H-indol-7-yl sulfamate
  • 2-(Oxan-4-yloxy)aniline;hydrochloride
  • methyl 2-[3-(morpholin-4-ylcarbonyl)-1H-pyrazol-1-yl]propanoate
  • Carbamic acid, N-(3-hydroxy-4,6-dimethylheptyl)-, 1,1-dimethylethyl ester
  • 1-(4-Aminopiperidin-1-yl)-3-[(2-hydroxypropyl)amino]propan-1-one
  • Benzoic acid, 4-(3-chloro-1-oxopropyl)-3-(hydroxymethyl)-, methyl ester
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-(ethylsulfanyl)pyridine-2-carboxylate
  • CID 163338221
  • (3R,4R)-4-Amino-1-benzylpiperidin-3-ol dihydrochloride
  • CID 163338244
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