Octamethylcyclotetrasiloxane

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Names

[ CAS No. ]:
556-67-2

[ Name ]:
Octamethylcyclotetrasiloxane

[Synonym ]:
EINECS 209-136-7
Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
Octamethylcyclotetrasiloxane
MFCD00003269
2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
175.0±0.0 °C at 760 mmHg

[ Melting Point ]:
17-18 °C(lit.)

[ Molecular Formula ]:
C₈H₂₄O₄Si₄

[ Molecular Weight ]:
296.616

[ Flash Point ]:
63.2±23.0 °C

[ Exact Mass ]:
296.075165

[ PSA ]:
36.92000

[ LogP ]:
2.87360

[ Vapour density ]:
1 (vs air)

[ Vapour Pressure ]:
1.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.423

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4397000

CHEMICAL NAME :: Cyclotetrasiloxane, octamethyl-

CAS REGISTRY NUMBER :: 556-67-2

BEILSTEIN REFERENCE NO. :: 1787074

LAST UPDATED :: 199712

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C8-H24-O4-Si4

MOLECULAR WEIGHT :: 296.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 gm/m3/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1770 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 794 uL/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530406

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 697 ppm/6H/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 697 ppm/6H/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3232 No. of Facilities: 128 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 3383 (estimated) No. of Female Employees: 1689 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H361-H413

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R53;R62

[ Safety Phrases ]:
S36/37-S46-S51-S61

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
GZ4397000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Water
Dichlorodimethylsilane
hexamethylcyclotrisiloxane
1-(1-Adamantyl)-2-diazo-2-(pentamethyldisilanyl)ethanone
dimethylsilanediol
Methyltrichlorosilane
Diethoxydimethylsilane
Tetrachlorosilane

DownStream

Octamethyltrisiloxane
Decamethyltetrasiloxane
Dodecamethylpentasiloxane
Tetradecamethylhexasiloxane
Hexadecamethylheptasiloxane
TMS
Trimethylsilyl iodide
Hexamethyldisiloxane
Decamethylcyclopentasiloxane
Dodecamethylcyclohexasiloxane

Articles

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Environ. Technol. 30(10) , 1073-83, (2009)

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Environ. Pollut. 190 , 109-14, (2014)

Spatial distribution and relationship of allometric measurements (length, weight and age) to liver concentrations of cyclic volatile methyl siloxanes (cVMS) including octamethylcyclotetrasiloxane (D4)...

[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa].

Zhong Yao Cai 31(5) , 677-8, (2008)

To analyze the volatile oils chemical constituents of roots of Actinidia deliciosa.The volatile oils fraction of roots of Actinidia deliciosa. were extracted by water vapor distilling, and then the co...

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