Octamethylcyclotetrasiloxane

Modify Date: 2024-01-02 18:10:51

Octamethylcyclotetrasiloxane structure	Common Name	Octamethylcyclotetrasiloxane
	CAS Number	556-67-2	Molecular Weight	296.616
	Density	1.0±0.1 g/cm3	Boiling Point	175.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₂₄O₄Si₄	Melting Point	17-18 °C(lit.)
	MSDS	Chinese USA	Flash Point	63.2±23.0 °C
	Symbol	GHS02, GHS08	Signal Word	Warning

Name	octamethylcyclotetrasiloxane
Synonym	More Synonyms

Density	1.0±0.1 g/cm3
Boiling Point	175.0±0.0 °C at 760 mmHg
Melting Point	17-18 °C(lit.)
Molecular Formula	C₈H₂₄O₄Si₄
Molecular Weight	296.616
Flash Point	63.2±23.0 °C
Exact Mass	296.075165
PSA	36.92000
LogP	2.87360
Vapour density	1 (vs air)
Vapour Pressure	1.6±0.3 mmHg at 25°C
Index of Refraction	1.423
Storage condition	2-8°C
Water Solubility	INSOLUBLE

Octamethylcyclotetrasiloxane MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4397000

CHEMICAL NAME :: Cyclotetrasiloxane, octamethyl-

CAS REGISTRY NUMBER :: 556-67-2

BEILSTEIN REFERENCE NO. :: 1787074

LAST UPDATED :: 199712

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C8-H24-O4-Si4

MOLECULAR WEIGHT :: 296.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1230,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 gm/m3/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1770 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 794 uL/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538262 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530406

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 697 ppm/6H/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 697 ppm/6H/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516677 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3232 No. of Facilities: 128 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 3383 (estimated) No. of Female Employees: 1689 (estimated)

Symbol	GHS02, GHS08
Signal Word	Warning
Hazard Statements	H226-H361-H413
Precautionary Statements	P281
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R53;R62
Safety Phrases	S36/37-S46-S51-S61
RIDADR	UN 1993 3/PG 3
WGK Germany	1
RTECS	GZ4397000
Packaging Group	III
Hazard Class	3

Precursor 8
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EINECS 209-136-7

Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-

Octamethylcyclotetrasiloxane

MFCD00003269

2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane

2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane