L-glutamic acid

Names

[ CAS No. ]:
56-86-0

[ Name ]:
L-glutamic acid

[Synonym ]:
L-Glutamic acid
Glusate
H-L-GLU-OH
L-GLU
H-GLU-OH
GLU
L-Glutamicacid
GLUTACID
Aciglut
EINECS 200-293-7
MFCD00002634
glutamic
Glutaton
(S)-Glutamic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
333.8±32.0 °C at 760 mmHg

[ Melting Point ]:
205 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₉NO₄

[ Molecular Weight ]:
147.129

[ Flash Point ]:
155.7±25.1 °C

[ Exact Mass ]:
147.053162

[ PSA ]:
100.62000

[ LogP ]:
-1.43

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Water Solubility ]:
7.5 g/L (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ9700000

CHEMICAL NAME :: Glutamic acid, L-

CAS REGISTRY NUMBER :: 56-86-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H9-N-O4

MOLECULAR WEIGHT :: 147.15

WISWESSER LINE NOTATION :: QVYZ2VQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Behavioral - headache

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >30 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80420 No. of Facilities: 446 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 10592 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80420 No. of Facilities: 915 (estimated) No. of Industries: 10 No. of Occupations: 27 No. of Employees: 11240 (estimated) No. of Female Employees: 5754 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
LZ9700000

[ HS Code ]:
2922421000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-allyloxycarbonyl α-allyl-L-glutamate
Z-Glu(OBzl)-OH
H-Glu(OBzl)-OH
(S)-(N-benzyl-N-benzyloxycarbonyl)glutamic acid
(5S)-1-tert-butoxycarbonyl-5-(5-methyl-2,7,8-trioxabicyclo[3.2.1]oct-1-yl)-5H-pyrrolin-2-one
DL-Glutamic acid
3-[3-((allyloxy)carbonyl)-5-oxo-1,3-oxazolan-4-yl]propanoic acid
(S)-3-BENZYLOXYCARBONYL-5-OXO-4-OXAZOLIDINEPROPANOIC ACID
Fmoc-Glu(OtBu)-OH
2-Ketoglutaric acid

DownStream

(2S)-2-(decanoylamino)pentanedioic acid
Dimethylamine
methylamine
Trimethylamine
(5S)-5-[[[(tert-Butyl)dimethylsilyl]oxy]methyl]-2-pyrrolidinone
(2S)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]pentanedioic acid
Boc-Glu(OMe)-OH
pyridoxamine phosphate
pth-l-glutamic acid
N-phthaloyl-L-glutamic acid

Customs

[ HS Code ]: 2922421000

[ Summary ]:
HS: 2922421000. (s)-2-aminopentanedioic acid. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:10.0%. general tariff:90.0%

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