L-glutamic acid

Modify Date: 2026-06-30 19:24:31

L-glutamic acid Structure
L-glutamic acid structure
Common Name L-glutamic acid
CAS Number 56-86-0 Molecular Weight 147.129
Density 1.4±0.1 g/cm3 Boiling Point 333.8±32.0 °C at 760 mmHg
Molecular Formula C5H9NO4 Melting Point 205 °C (dec.)(lit.)
MSDS USA Flash Point 155.7±25.1 °C

 Use of L-glutamic acid


(S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name L-glutamic acid
Synonym More Synonyms

 L-glutamic acid Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description (S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
Related Catalog
Target

Human Endogenous Metabolite

DA

References

[1]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.4±0.1 g/cm3
Boiling Point 333.8±32.0 °C at 760 mmHg
Melting Point 205 °C (dec.)(lit.)
Molecular Formula C5H9NO4
Molecular Weight 147.129
Flash Point 155.7±25.1 °C
Exact Mass 147.053162
PSA 100.62000
LogP -1.43
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.522
Water Solubility 7.5 g/L (20 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ9700000
CHEMICAL NAME :
Glutamic acid, L-
CAS REGISTRY NUMBER :
56-86-0
LAST UPDATED :
199706
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C5-H9-N-O4
MOLECULAR WEIGHT :
147.15
WISWESSER LINE NOTATION :
QVYZ2VQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
71 mg/kg
TOXIC EFFECTS :
Behavioral - headache
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>30 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80420 No. of Facilities: 446 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 10592 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80420 No. of Facilities: 915 (estimated) No. of Industries: 10 No. of Occupations: 27 No. of Employees: 11240 (estimated) No. of Female Employees: 5754 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS LZ9700000
HS Code 2922421000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2922421000
Summary HS: 2922421000. (s)-2-aminopentanedioic acid. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:10.0%. general tariff:90.0%

 Articles365

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.

J. Neurosci. 34(40) , 13472-85, (2014)

The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit...

Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling

J. Steroid Biochem. Mol. Biol. 144 Pt B , 334-47, (2014)

• Age-dependent action of nonylphenol (NP) on mouse neuronal cells was demonstrated. • Estrogen receptor (ER) antagonists potentiated the NP-induced apoptosis and toxicity. • ER agonists inhibited the...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

L-Glutamic acid
Glusate
H-L-GLU-OH
L-GLU
H-GLU-OH
GLU
L-Glutamicacid
GLUTACID
Aciglut
EINECS 200-293-7
MFCD00002634
glutamic
Glutaton
(S)-Glutamic acid

 L-glutamic acid | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of L-glutamic acid?
A: Molecular formula of L-glutamic acid is C5H9NO4.
Q: What is the English name of L-glutamic acid?
A: The English name of L-glutamic acid is L-glutamic acid.
Q: What is the molecular weight of L-glutamic acid?
A: Molecular weight of L-glutamic acid is 147.129.
Q: How is the water solubility of L-glutamic acid?
A: Water solubility of L-glutamic acid: 7.5 g/L (20 ºC).
Q: What are the uses of L-glutamic acid?
A: Main uses of L-glutamic acid: (S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
Q: What are the downstream products of L-glutamic acid?
A: Related downstream products(CAS) of L-glutamic acid: 111276-71-2;124-40-3;74-89-5;75-50-3;106191-02-0;1101-68-4;45214-91-3;529-96-4;5624-27-1;340-90-9.
Q: What English synonyms does L-glutamic acid have?
A: English synonyms of L-glutamic acid: L-Glutamic acid, Glusate, H-L-GLU-OH, L-GLU, H-GLU-OH, GLU, L-Glutamicacid, GLUTACID, Aciglut, EINECS 200-293-7, MFCD00002634, glutamic, Glutaton, (S)-Glutamic acid.
Q: What is the polar surface area (PSA) of L-glutamic acid?
A: Polar surface area (PSA) of L-glutamic acid is 100.62000.
Q: What is the boiling point of L-glutamic acid?
A: Boiling point of L-glutamic acid is 333.8±32.0 °C at 760 mmHg.
Q: What is the melting point of L-glutamic acid?
A: Melting point of L-glutamic acid is 205 °C (dec.)(lit.).

 L-glutamic acidfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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