1-Nitrosopiperazine

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Names

[ CAS No. ]:
5632-47-3

[ Name ]:
1-Nitrosopiperazine

[Synonym ]:
1-Nitrosopiperazine
Piperazine, 1-nitroso-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
264.5±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H9N3O

[ Molecular Weight ]:
115.134

[ Flash Point ]:
113.8±25.4 °C

[ Exact Mass ]:
115.074562

[ PSA ]:
44.70000

[ LogP ]:
0.18

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.602

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM2450000
CHEMICAL NAME :
Piperazine, 1-nitroso-
CAS REGISTRY NUMBER :
5632-47-3
BEILSTEIN REFERENCE NO. :
0112147
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C4-H9-N3-O
MOLECULAR WEIGHT :
115.16
WISWESSER LINE NOTATION :
T6M DNTJ DNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2260 mg/kg
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5400 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Reproductive - Tumorigenic effects - uterine tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - tumors

MUTATION DATA

TYPE OF TEST :
Host-mediated assay
TEST SYSTEM :
Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION :
150 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 272,161,1992

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperazine
  • Methylnitronitrosoguanidine
  • trimethylnitrosourea
  • N',N'-dimethyl-N-ethyl-N-nitrosourea
  • Ethyl methyl(nitroso)carbamate
  • diethylmethylnitrosourea
  • N-Nitroso-N-methylurea
  • Piperidinium formate
  • Nitrous acid, propylester

DownStream

  • 1-Aminopiperazine
  • 1-benzyl-4-nitrosopiperazine
  • Piperazine
  • 4-Cyclopentyl-1-piperazinamine

Related Compounds

  • 1-Nitrosopiperazine-d8
  • 3,5-dimethyl-1-nitrosopiperazine
  • 2,4,6-trimethyl-1-nitrosopiperazine
  • 4-Butyl-2-methyl-1-nitrosopiperazine
  • 4-tert-butoxycarbonyl-1-nitrosopiperazine
  • (2S,6R)-2,4,6-trimethyl-1-nitrosopiperazine
  • 2-Chloro-1-[3-(6-cyclopropylamino-pyrimidin-4-yloxy)-piperidin-1-yl]-ethanone
  • 2-Chloro-6,7-dihydro-1,7-naphthyridin-8(5H)-one
  • 4-(4-((5-Chloropyridin-2-yl)oxy)piperidine-1-carbonyl)-1-phenylpyrrolidin-2-one
  • 3-(1H-Benzoimidazol-2-ylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
  • 3-(1H-Benzoimidazol-2-ylsulfanylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
  • 3-(2-Chloro-pyrimidin-4-ylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
  • 3-(2-Chloro-pyrimidin-4-ylsulfanylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
  • 3-(2-Chloro-thiazol-5-ylmethylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester
  • 3-(2-Chloro-thiazol-5-ylmethylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
  • 3-(2-Chloro-thiazol-5-ylmethylsulfanylmethyl)-piperidine-1-carboxylic acid tert-butyl ester
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