Betahistine
Suppliers
Names
[ CAS No. ]:
5638-76-6
[ Name ]:
Betahistine
[Synonym ]:
2-(b-Methylaminoethyl)pyridine
N-methyl-2-pyridin-2-ylethanamine
Pyridine, 2-[2- (methylamino)ethyl]-
MFCD00006362
N-Methyl-2-(2-pyridinyl)ethanamine
EINECS 227-086-4
Suzutolon
2-Pyridineethanamine, N-methyl-
2-(2-Methylaminoethyl)pyridine
N-methyl-2-(pyridin-2-yl)ethanamine
N-Methyl-2-pyridineethanamine
Betahistine
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
210.9±15.0 °C at 760 mmHg
[ Molecular Formula ]:
C8H12N2
[ Molecular Weight ]:
136.194
[ Flash Point ]:
96.7±0.0 °C
[ Exact Mass ]:
136.100052
[ PSA ]:
24.92000
[ LogP ]:
0.10
[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.510
[ Storage condition ]:
-20℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT5552000
- CHEMICAL NAME :
- Pyridine, 2-(2-(methylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 5638-76-6
- BEILSTEIN REFERENCE NO. :
- 0112294
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C8-H12-N2
- MOLECULAR WEIGHT :
- 136.22
- WISWESSER LINE NOTATION :
- T6NJ B2M1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 980 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2920 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 94500 mg/kg/90D-C
- TOXIC EFFECTS :
- Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,344,1968
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi: Irritant;C: Corrosive;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
UN2735
[ WGK Germany ]:
2
[ RTECS ]:
UT5552000
[ HS Code ]:
2933399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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