4-Methoxyphenylboronic acid

Suppliers

Names

[ Name ]:
4-Methoxyphenylboronic acid

[Synonym ]:
p-methoxy phenyl boronic acid
p-Anisylboronic acid
4-Boronoanisole
4-methoxy phenylboronic acid
MFCD00039139
p-Methoxyphenylboronic acid
para-methoxyphenylboronic acid
4-Methoxyphenylboronic acid
RARECHEM AH PB 0191
EINECS 216-845-5
(4-Methoxyphenyl)boronic acid
4-Anisylboronic acid
4-Methoxyphenylboron
4-Methoxybenzeneboronic acid
Boronic acid, B-(4-methoxyphenyl)-
p-Methoxybenzeneboronic acid
4-methoxyphenylboronicacid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
306.8±44.0 °C at 760 mmHg

[ Melting Point ]:
204-206 °C(lit.)

[ Molecular Formula ]:
C₇H₉BO₃

[ Molecular Weight ]:
151.96

[ Flash Point ]:
139.3±28.4 °C

[ Exact Mass ]:
152.064468

[ PSA ]:
49.69000

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.524

[ Storage condition ]:
Refrigerator (+4°C)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY8975000

CHEMICAL NAME :: Benzeneboronic acid, p-methoxy-

CAS REGISTRY NUMBER :: 5720-07-0

BEILSTEIN REFERENCE NO. :: 2936912

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-B-O3

MOLECULAR WEIGHT :: 151.97

WISWESSER LINE NOTATION :: QBQR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00062

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CY8975000

[ HS Code ]:
29310095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Bromoanisole
4-Iodoanisole
4-Methoxyphenyl Trifluoromethanesulfonate
4-Anisylmagnesium bromide
Triethyl borate
Trimethyl borate
Triisopropylborate
1-Chloro-4-methoxybenzene
Sulfuric acid
4-Methoxyphenylboronic Acid Pinacol Ester

DownStream

3,4-bis(4-methoxyphenyl)pyrrole-2,5-dione
4-PYRAZIN-2-YLPHENOL
3-(4-methoxyphenyl)cycloheptan-1-one
2-(4-Methoxyphenyl)pyrazine
1-decyl-4-(4-methoxyphenyl)benzene
4-Bromo-2-(4-methoxyphenyl)thiazole
4-methoxyphenylphosphonic acid diethyl ester
Bis(4-methoxyphenyl) sulfide
4-(4-Methoxyphenyl)pyridine
5-(4-Methoxyphenyl)thiophene-2-carboxaldehyde

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

Bioorg. Med. Chem. Lett. 19 , 2642-5, (2009)

Inhibition of the beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of aromatic, arylalkenyl- and arylalky...

Ruthenium(0)-catalyzed sp3 C-H bond arylation of benzylic amines using arylboronates.

Org. Lett. 7th ed., 14 , 1930-1933, (2012)

A Ru-catalyzed direct arylation of benzylic sp(3) carbons of acyclic amines with arylboronates is reported. This highly regioselective and efficient transformation can be performed with various combin...

Tandem-type Pd(II)-catalyzed oxidative Heck reaction/intramolecular C-H amidation sequence: a novel route to 4-aryl-2-quinolinones.

Chem. Commun. (Camb.) 36th ed., 48 , 4332-4334, (2012)

A novel catalytic method for synthesizing 4-aryl-2-quinolinones is reported. The process involves two mechanistically independent, sequential Pd(II)-catalyzed reactions--the oxidative Heck reaction an...