N-Boc-piperazine

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Names

[ CAS No. ]:
57260-71-6

[ Name ]:
N-Boc-piperazine

[Synonym ]:
piperazine-1-carboxylic acid tert-butyl ester
1-Piperazinecarboxylic acid, 1,1-dimethylethyl ester
BOC-PIPERAZINE
2-Methyl-2-propanyl 1-piperazinecarboxylate
1-Boc piperzine
t-Butyl 1-piperazincarboxylate
tert-butyl piperazine-1-carboxylate
1,1-Dimethylethyl 1-piperazinecarboxylate
1-BOC-Piperazine
PIBOC
MFCD00075265
tert-butyl tetrahydropyrazine-1(2H)-carboxylate
N-BOC-PIPERAZINE
tert-butyl l-piperazinecarboxylate
1-N-BOC-PIPERAZINE
RARECHEM AR PA 0026
BOC-PAZ
N-Boc-piperazine; tert-butyl piperazine-1-carboxylate
tert-Butyl 1-piperazinecarboxylate
N-Boc-piperazine
N Boc-Piperazine

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
258.0±15.0 °C at 760 mmHg

[ Melting Point ]:
47-49ºC

[ Molecular Formula ]:
C9H18N2O2

[ Molecular Weight ]:
186.251

[ Flash Point ]:
109.8±20.4 °C

[ Exact Mass ]:
186.136826

[ PSA ]:
41.57000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperazine
  • Di-tert-butyl dicarbonate
  • TERT-BUTYL 4-(METHYLSULFONYL)PIPERAZINE-1-CARBOXYLATE
  • 1-tert-Butyl 4-methyl piperazine-1,4-dicarboxylate
  • tert-butyl 4-benzylpiperazine-1-carboxylate
  • Piperazine-1,4-dicarboxylic acid benzyl ester tert-butyl ester
  • 3-Methylxanthine
  • 1-Bromo-2-butyne
  • 8-Chlorotheophyline

DownStream

  • 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine
  • tert-butyl 4-(3-bromophenyl)piperazine-1-carboxylate
  • 1-(4-Chlorophenyl)piperazine
  • tert-butyl 4-(5-iodopyridin-2-yl)piperazine-1-carboxylate
  • 1-(2-furoyl)piperazine
  • tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate
  • 1-(2-Chlorophenyl)piperazine
  • 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine
  • tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate
  • tert-Butyl 4-(2-bromophenyl)piperazine-1-carboxylate

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.

J. Enzyme Inhib. Med. Chem. , (2013)

A series of new 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones have been synthesized and evaluated for dual D2 and 5-HT1A receptor binding affinities. The synthesized ligands are struc...

Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

Bioorg. Med. Chem. Lett. 14 , 2857-2862, (2004)

In this study, we report the design, synthesis and structure-activity relationships of novel indazole derivatives as DNA gyrase inhibitors with Gram-positive antibacterial activity. Our results show t...

Molecular iodine-catalyzed facile procedure for N-Boc protection of amines.

J. Org. Chem. 71 , 8283, (2006)

An efficient and practical protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of molecular i...


More Articles

Related Compounds

  • N-Boc-piperazine
  • N-Boc-piperazine-d8
  • N-Boc-piperazine-¹³C4
  • N-Boc-piperazine-C3-COOH
  • N-Boc-piperazine-N'-sulfamate
  • N-Boc-piperazine-2-amidoanhydride
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 4-(4-fluorophenyl)-2-(3-methoxybenzyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide
  • 2-Bromo-6-(oxolan-3-yl)pyridine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methylacetamide