4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid

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Names

[ CAS No. ]:
574-92-5

[ Name ]:
4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid

[Synonym ]:
MFCD00006771
4-hydroxy-7-trifluoromethyl-3-quinoline-carboxylic acid
EINECS 209-377-8
4-Hydroxy-7-trifluoromethyl-3-quinolinecarboxylic acid,HPLC
4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID
4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylicaci
4-Hydroxy-7-trifluormethyl-chinolin-3-carbonsaeure
3-Carboxy-4-hydroxy-7-trifluoromethylquinoline.
7-trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid
BUTTPARK 219-48
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINE-CARBOXYLIC ACID,TECH.

Chemical & Physical Properties

[ Density]:
1.55 g/cm3

[ Boiling Point ]:
354.7ºC at 760 mmHg

[ Melting Point ]:
259-260 °C (dec.)(lit.)

[ Molecular Formula ]:
C11H6F3NO3

[ Molecular Weight ]:
257.16500

[ Flash Point ]:
168.3ºC

[ Exact Mass ]:
257.03000

[ PSA ]:
70.42000

[ LogP ]:
2.65740

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VB2188000
CHEMICAL NAME :
3-Quinolinecarboxylic acid, 4-hydroxy-7-(trifluoromethyl)-
CAS REGISTRY NUMBER :
574-92-5
BEILSTEIN REFERENCE NO. :
0249406
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H6-F3-N-O3
MOLECULAR WEIGHT :
257.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 9,585,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VB2188000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Quinolinecarboxylicacid, 4-hydroxy-7-(trifluoromethyl)-, ethyl ester
  • Propanedioic acid,2-[[[3-(trifluoromethyl)phenyl]amino]methylene]-, 1,3-diethyl ester
  • 3-(Trifluoromethyl)aniline

DownStream

  • 4-Chloro-7-trifluoromethylquinoline
  • 7-(Trifluoromethyl)-4-quinolinol
  • N,N-diethyl-N-[7-(trifluoromethyl)quinolin-4-yl]pentane-1,4-diamine

Articles

Synthesis and testing of new antileukemic Schiff bases of N-hydroxy-N'-aminoguanidine against CCRF-CEM/0 human leukemia cells in vitro and synergism studies with cytarabine (Ara-C).

Pharm. Res. 10(4) , 515-20, (1993)

A series of eight new N-hydroxy-N'-aminoguanidine (HAG) Schiff bases [ArCH = NNHC(= NH)NHOH.tosylate] was synthesized as potential antitumor agents through the inhibition of the enzyme ribonucleotide ...


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Related Compounds

  • 2-{4-[(Trifluoromethyl)sulfanyl]phenyl}propan-1-amine
  • 1-(5-Chloro-2-nitrophenyl)-2,2-dimethylcyclopropan-1-amine
  • 3-Amino-1-[2-(piperidin-1-yl)pyridin-3-yl]propan-1-ol
  • tert-butyl N-[4-(3-amino-2,2-dimethylcyclopropyl)-3-hydroxyphenyl]carbamate
  • O-[2-methyl-2-(1-methyl-1H-imidazol-2-yl)propyl]hydroxylamine
  • tert-butyl N-[2-oxo-1-(2,4,5-trifluorophenyl)ethyl]carbamate
  • (1-{[6-(Propan-2-yloxy)pyridin-2-yl]methyl}cyclopropyl)methanamine
  • methyl (3R)-3-(2,3-dihydro-1H-inden-1-yl)-3-hydroxypropanoate
  • 2-(2-Chloro-1,3-thiazol-5-yl)-2-methylpropan-1-ol
  • methyl (3S)-3-hydroxy-3-(5-methoxypyridin-3-yl)propanoate
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