Docusate sodium
Suppliers
Names
[ CAS No. ]:
577-11-7
[ Name ]:
Docusate sodium
[Synonym ]:
sbo
Octowet
Nikkol OTP 100
DOSS
Astrowet 608
DIOX
Dioctyl sodium sulfosuccinate
Docusate sodium salt
Gemtex SC 40
Nikkol OTP 100S
Sanseparer 100
Geropon SS-O 75
Rapisol B 90
nevax
Bis(ethylhexyl) ester of sodium sulfosuccinic acid
Pentex 99
Dioctyl ester of sodium sulfosuccinate
Empimin OP 70
Neocol YSK
Sunnol LDF 110
Aerosol OT 100
Di-(2-ethylhexyl) sodium sulfosuccinate
sv102
colace
Triton GR 5
Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxo-2-butanesulfonate
Newcol 290M
Rapisol B 80
Rewopol SBDO 70
sodium bis(2-ethylhexyl) sulfosuccinate
Sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt
Gemtex SC
Lumiten I-RA
Valsol OT
Bis(2-ethylhexyl)sodium sulfosuccinate
Rapisol A 30
Solusol
doxol
Neopelex OTP
Airrol OP
Newcol 291M
Lankropol KO 2
Triton GR 7M
Newkalgen EP 60P
Solovet
revac
Geropon DOS
Astrowet O 70PG
Dioctyl sulfosuccinate sodium salt
Marlinat DF 8
Astrowet O 75
Persol KMN 3
Monawet MO 70R
coprol
Nikkol OTP 75
Triton GR 7ME
Aerosol OT 75PG
Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
Aerosol OT-S
Spilon 8
Jamylene
Sodium Di(2-ethylhexyl) Sulfosuccinate
Pelex OT
Empimin OT 75
Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
DSS
Rapisol A 80
Triton GR 5M
Succinate STD
Pelex OT-P
Sulfosuccinic Acid 1,4-Bis(2-ethylhexyl) Ester S-Sodium Salt
Genopur SB 1970J
Lutensit A-BO
Bis(2-ethylhexyl) Sulfosuccinate Sodium Salt
Lutensit A-BOS
Docusate sodium
Neocol P
Di(2-ethylhexyl)sulfosuccinic acid, sodium salt
sodium dioctyl sulfosuccinate
Manoxol
Newkalgen EP 70G
Surfonic DOS 75PG
BIS(2-ETHYLHEXYL) SULFOSUCCINATE, SODIUM SALT
Monawet M 085P
Pionin A 51B
Geropon WT 27
EINECS 209-406-4
NK-EP 70G
Warcowet 060
Drewfax 007
Aerosol OT 94
Newcol 291EG
AOT
Nonit
Sodium Docusate
Airrol CT 1
Isoprotanc
Manoxol OP
MFCD00012455
Monawet MO 70
Sanmorin OT 70N
Freetex OT
Rapisol B 30
KM 10-1610
Monawet MO 70E
Docusate (Sodium)
Chemical & Physical Properties
[ Density]:
1.1
[ Melting Point ]:
173-179 °C(lit.)
[ Molecular Formula ]:
C20H37NaO7S
[ Molecular Weight ]:
444.558
[ Flash Point ]:
199ºC
[ Exact Mass ]:
444.215759
[ PSA ]:
118.18000
[ LogP ]:
4.89030
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
1.5 g/100 mL (25 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WN0525000
- CHEMICAL NAME :
- Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
- CAS REGISTRY NUMBER :
- 577-11-7
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C20-H38-O7-S.Na
- MOLECULAR WEIGHT :
- 445.63
- WISWESSER LINE NOTATION :
- 2Y2&3OVYSWQ1VO3Y2&2 &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,377,1944
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 34,99,1945
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 13,469,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 590 mg/kg
- TOXIC EFFECTS :
- Vascular - structural changes in vessels
- REFERENCE :
- BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 7,161,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2643 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,89,1977/1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/12W-C
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
- REFERENCE :
- BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 9,159,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 gm/kg/30D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,428,1949
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 84 mg/kg/24W-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,175,1943 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 8820 mg/kg
- SEX/DURATION :
- multigeneration
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - other postnatal measures or effects
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 15,53,1990 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83280 No. of Facilities: 3817 (estimated) No. of Industries: 53 No. of Occupations: 74 No. of Employees: 45527 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83280 No. of Facilities: 11668 (estimated) No. of Industries: 95 No. of Occupations: 100 No. of Employees: 180694 (estimated) No. of Female Employees: 49329 (estimated)
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H318
[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S39-S37/39-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
WN0525000
[ HS Code ]:
2914509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914509090
[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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