8-Aminoquinoline

Suppliers

Names

[ CAS No. ]:
578-66-5

[ Name ]:
8-Aminoquinoline

[Synonym ]:
8-Quinolinamine
MFCD00006809
quinolin-8-amine
EINECS 209-427-9
8-Aminoquinoline

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
289.8±0.0 °C at 760 mmHg

[ Melting Point ]:
62-65ºC

[ Molecular Formula ]:
C9H8N2

[ Molecular Weight ]:
144.17

[ Flash Point ]:
171.5±8.1 °C

[ Exact Mass ]:
144.068741

[ PSA ]:
38.91000

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.708

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA9627000
CHEMICAL NAME :
Quinoline, 8-amino-
CAS REGISTRY NUMBER :
578-66-5
BEILSTEIN REFERENCE NO. :
0114474
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C9-H8-N2
MOLECULAR WEIGHT :
144.19
WISWESSER LINE NOTATION :
T66 BNJ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
480 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Leukocyte
DOSE/DURATION :
100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,285,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38;R68

[ Safety Phrases ]:
S22-S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VA9627000

[ HS Code ]:
29334990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 8-Nitroquinoline
  • 4-Chloro-8-nitroquinoline
  • 8-Chloroquinoline
  • N-Methylpyrrolidone
  • 8-Hydroxyquinoline
  • 2-Bromo-2-methylpropanamide
  • Methanol
  • 8-azidoquinoline

DownStream

  • 4H-Imidazo[4,5,1-ij]quinoline-2-methanol,5,6-dihydro-(6CI,9CI)
  • 8-Fluoroquinoline
  • 8-(Trifluoromethyl)quinoline
  • 8-benzylaminoquinoline
  • 8-Hydrazinylquinoline
  • Palladium,dichloro(8-quinolinamine-N1,N8)-, (SP-4-3)- (9CI)
  • 4-Chloro-1,10-phenanthroline
  • 1,10-Phenanthroline
  • ethyl N-quinolin-8-ylcarbamate
  • 8-Quinolineboronic acid

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.

Malaria Journal 11 , 259, (2012)

The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale...

Aminoquinolines as fluorescent labels for hydrophilic interaction liquid chromatography of oligosaccharides.

Biol. Chem. 393(8) , 757-65, (2012)

In this study, we investigated the potential of four different aminoquinoline (AQ) compounds as fluorescent labels for glycan analysis using hydrophilic interaction liquid chromatography (HILIC) and f...

Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model.

PLoS ONE 7(8) , e43105, (2012)

Alzheimer's disease (AD) is a neurodegenerative syndrom involving many different biological parameters, including the accumulation of copper metal ions in Aβ amyloid peptides due to a perturbation of ...


More Articles

Related Compounds

  • 8-aminoquinoline
  • 8-Aminoquinoline
  • 8-Aminoquinoline N-Oxide
  • 3-bromo-8-aminoquinoline
  • 5-Bromo-8-aminoquinoline
  • 6-Bromo-8-aminoquinoline
  • 1-[(1-Benzylpiperidin-3-yl)methyl]cyclopropan-1-amine
  • Tert-butyl 3-amino-3-(2-methoxyethyl)pyrrolidine-1-carboxylate
  • Tert-butyl 4-(aminomethyl)-4-hydroxy-3-methyl-piperidine-1-carboxylate
  • {1-[(Dimethylamino)methyl]cyclobutyl}methanamine
  • 5-(2-Methylpropyl)-1,2,3,4-tetrahydroquinoline
  • 4-Amino-2-(1-methylcyclopropyl)butan-2-OL
  • 3-(Aminomethyl)-2-(1-methylcyclopropyl)hexan-2-ol
  • 2-Acetyl-4-methyl-N-(2-phenylethyl)pentanamide
  • 2-acetyl-4-methyl-N-(2-phenylethyl)-4-pentenamide
  • 1-[(prop-2-en-1-yloxy)carbonyl]-2,3-dihydro-1H-indole-3-carboxylic acid
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