Adenosine

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Names

[ CAS No. ]:
58-61-7

[ Name ]:
Adenosine

[Synonym ]:
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Adenosin
β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-
9β-D-ribofuranosyl-9H-Purin-6-amine
Adesine
1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-Ribofuranose
6-Amino-9-b-D-ribofuranosyl-9H-purine
Adenocor
Sandesin
(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol
9-β-δ-Ribofuranosidoadenine
(-)-adenosine
9-β-δ-Ribofuranosyl-9H-purin-6-amine
(–)-adenosine
9-b-D-Ribofuranosidoadenine
D-Adenosine
MFCD00005752
Adenosine
Adenine-9-beta-D-ribofuranoside
Adrekar
9-β-D-Ribofuranosyladenine
9-beta-D-Ribofuranosyladenine
9-b-D-Ribofuranosyl-9H-purin-6-amine
Boniton
Adenine riboside
Adenoscan
adenine-9β-D-Ribofuranoside
Adenocard
EINECS 200-389-9
9-β-D-Arabinofuranosyladenine
Myocol

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
676.3±65.0 °C at 760 mmHg

[ Melting Point ]:
234-236ºC

[ Molecular Formula ]:
C10H13N5O4

[ Molecular Weight ]:
267.241

[ Flash Point ]:
362.8±34.3 °C

[ Exact Mass ]:
267.096741

[ PSA ]:
139.54000

[ LogP ]:
-1.02

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.907

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7175000
CHEMICAL NAME :
Adenosine
CAS REGISTRY NUMBER :
58-61-7
LAST UPDATED :
199701
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C10-H13-N5-O4
MOLECULAR WEIGHT :
267.28
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
240 ug/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
143 ug/kg/I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - headache
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
50 ug/kg/1M-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiolar constriction
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
360 ug/kg/1H-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Cardiac - change in rate
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
257 ug/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
171 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - pulse rate
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
257 ug/kg/1D-I
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
60 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3937 No. of Facilities: 77 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 556 (estimated) No. of Female Employees: 387 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
AU7175000

[ HS Code ]:
2934999090

Synthetic Route

Precursor & DownStream

Precursor

  • 8-Bromoadenosine
  • Adenosine,5'-O-(triphenylmethyl)-
  • 2',3'-O-Isopropylideneadenosine
  • 5'-O-dimethoxytrityladenosine
  • 6H-Purin-6-imine, 1,7-dihydro- (9CI)
  • Uridine
  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-phenylmethoxyoxolan-3-ol
  • 1-acetyl-2,3,5-tri-o-benzoyl-b-l-ribofuranose
  • 2',3',5'-Tri-O-acetyladenosine

DownStream

  • [(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-azidooxolan-2-yl]methanol
  • 2',3'-Dideoxyadenosine
  • Pyridine chlorhydrate
  • N6,2',3',5'-tetra-O-toluoyladenosine
  • 2-Methylbenzamide
  • Inosine,6-S-methyl-6-thio-
  • N6-Benzoyladenosine
  • 3'-O-benzoyladenosine
  • 1-Methyladenine
  • 3-Methyladenine

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • Adenosine
  • Adenosine
  • A-ADENOSINE
  • L-Adenosine
  • Adenosine-d2
  • adenosine-8-d
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  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • Aminoandarine
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide