Adenosine
Adenosine structure
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Common Name | Adenosine | ||
|---|---|---|---|---|
| CAS Number | 58-61-7 | Molecular Weight | 267.241 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 676.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C10H13N5O4 | Melting Point | 234-236ºC | |
| MSDS | Chinese USA | Flash Point | 362.8±34.3 °C | |
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P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation.
Thromb. Haemost. 112(1) , 142-50, (2014) ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influence thromboxane A2 (TXA2)-stimulated platelet functional res... |
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The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus.
FEBS Lett. 589(6) , 750-5, (2015) The cyclic AMP phosphodiesterases type 4 (PDE4s) are expressed in a cell specific manner, with intracellular targeting directed by unique N-terminal anchor domains. All long form PDE4s are phosphorylated and activated by PKA phosphorylation within their upstr... |
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Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.
J. Neurosci. 34(35) , 11769-80, (2014) Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hippocampus onto septal cells, and are therefore likely to als... |
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Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.
BMC Genomics 16 , 151, (2015) Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRN... |
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Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.
J. Neuropathol. Exp. Neurol. 74(2) , 132-47, (2015) Focal cortical dysplasia type IIB (FCDIIB) is a developmental malformation of the cerebral cortex that is associated with pharmacoresistant epilepsy. Overexpression of adenosine kinase (ADK) has been regarded as a pathologic hallmark of epilepsy. We hypothesi... |
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Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase.
J. Med. Chem. 52 , 5485-95, (2009) Mycobacterium tuberculosis adenosine-5'-phosphosulfate (APS) reductase is an iron-sulfur protein and a validated target to develop new antitubercular agents, particularly for the treatment of latent infection. To facilitate the development of potent and speci... |
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Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.
FASEB J. 29(2) , 597-610, (2015) Atherosclerosis is the major cause of death and disability in diabetic and obese subjects with insulin resistance. Akt2, a phosphoinositide-dependent serine-threonine protein kinase, is highly express in insulin-responsive tissues; however, its role during th... |
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Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.
EMBO Mol. Med. 7 , 904-17, (2015) Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice leads to impaired s... |
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Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy.
J. Neuroimmunol. 277(1-2) , 96-104, (2014) Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previou... |
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The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction.
Mol. Brain 8 , 80, (2015) Various protein kinase C (PKC) isoforms contribute to the phosphorylating activity that modulates neurotransmitter release. In previous studies we showed that nPKCε is confined in the presynaptic site of the neuromuscular junction and its presynaptic function... |