Inosine

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Names

[ CAS No. ]:
58-63-9

[ Name ]:
Inosine

[Synonym ]:
6-Oxopurine riboside
HXR
RIBOXINE
nosine
Ino
EINECS 200-390-4
9-β-δ-Ribofuranosylhypoxanthine
Hypoxanthine, 9-β-D-ribofuranosyl-
1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one
9-β-D-ribofuranosyl-Hypoxanthine
9-β-D-Ribofuranosylhypoxanthine
Inosie
9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one
INO 495
hypoxanthine
Oxiamin
9-b-D-Ribofuranosylhypoxanthine
Atorel
MFCD00066770
6H-Purin-6-one, 1,9-dihydro-9-β-D-ribofuranosyl-
9β-D-Ribofuranosylhypoxanthine
6-oxy-purine riboside
9H-Purin-6-ol, 9-β-D-ribofuranosyl-
9-β-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one
9-b-D-ribofuranosyl-Hypoxanthine
Inosine
9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one
T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q &&β-D-Ribo Form
Inosine (8CI,9CI)
Selfer

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
670.5±65.0 °C at 760 mmHg

[ Melting Point ]:
222-226 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₂N₄O₅

[ Molecular Weight ]:
268.226

[ Flash Point ]:
359.3±34.3 °C

[ Exact Mass ]:
268.080780

[ PSA ]:
133.49000

[ LogP ]:
-1.91

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.879

[ Water Solubility ]:
2.1 g/100 mL (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM7460000

CHEMICAL NAME :: Inosine

CAS REGISTRY NUMBER :: 58-63-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H12-N4-O5

MOLECULAR WEIGHT :: 268.26

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 558 gm/kg/93D-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 60 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4726 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1253 (estimated) No. of Female Employees: 904 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
NM7460000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Adenosine
Inosine, 6-O-methyl-
6-Chloropurine riboside
2',3',5'-Tri-O-acetylinosine
D-RIBULOSE 5-PHOSPHATE DISODIUM SALT
Hypoxanthine
D-Ribose
b-D-Ribofuranose 1-acetate 2,3,5-tribenzoate
2',3'-O-Isopropylideneinosine
2-(6-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

DownStream

1-(6-Chloro-9H-purin-9-yl)-1-deoxy-2,3-O-isopropylidene-beta-D-ribofuranuronoyl chloride
D-Ribose
Hypoxanthine
2',3',5'-Tri-O-acetylinosine
Ribavirin
9-((2R,5S)-5-(HYDROXYMETHYL)-2,5-DIHYDROFURAN-2-YL)-3H-PURIN-6(9H)-ONE
N-Benzyladenosine
9H-Purine,6-chloro-9-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-
N6-(2-Phenylethyl)adenosine
9-[3,4-dihydroxy-5-(iodomethyl)oxolan-2-yl]-3H-purin-6-one

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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