Inosine

Modify Date: 2025-08-20 18:43:42

Inosine structure	Common Name	Inosine
	CAS Number	58-63-9	Molecular Weight	268.226
	Density	2.1±0.1 g/cm3	Boiling Point	670.5±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂N₄O₅	Melting Point	222-226 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	359.3±34.3 °C

Use of Inosine

Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties. In vitro: Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] In vivo: The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2]

Name	inosine
Synonym	More Synonyms

Description	Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties. In vitro: Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] In vivo: The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2]
Related Catalog	Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Moore TL et al. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Aug 1. [2]. Welihinda AA et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun;28(6):552-60. [3]. Junqueira SC et al. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. Mol Neurobiol. 2016 Apr 30.

Density	2.1±0.1 g/cm3
Boiling Point	670.5±65.0 °C at 760 mmHg
Melting Point	222-226 °C (dec.)(lit.)
Molecular Formula	C₁₀H₁₂N₄O₅
Molecular Weight	268.226
Flash Point	359.3±34.3 °C
Exact Mass	268.080780
PSA	133.49000
LogP	-1.91
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.879
Water Solubility	2.1 g/100 mL (20 ºC)

Inosine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM7460000

CHEMICAL NAME :: Inosine

CAS REGISTRY NUMBER :: 58-63-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C10-H12-N4-O5

MOLECULAR WEIGHT :: 268.26

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 558 gm/kg/93D-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 60 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4726 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1253 (estimated) No. of Female Employees: 904 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	NM7460000
HS Code	2934999090

Precursor 10
CAS#:58-61-7 Adenosine CAS#:5746-29-2 Inosine, 6-O-methyl- CAS#:2004-06-0 6-Chloropurine ... CAS#:3181-38-2 2',3',5'-Tri-O-...
CAS#:108321-99-9 D-RIBULOSE 5-PH... CAS#:68-94-0 Hypoxanthine CAS#:50-69-1 D-Ribose CAS#:6974-32-9 b-D-Ribofuranos...
CAS#:2140-11-6 2',3'-O-Isoprop... CAS#:5746-27-0 2-(6-hydrazinyl...
DownStream 10
CAS#:104940-65-0 1-(6-Chloro-9H-... CAS#:50-69-1 D-Ribose CAS#:68-94-0 Hypoxanthine CAS#:3181-38-2 2',3',5'-Tri-O-...
CAS#:36791-04-5 Ribavirin CAS#:42867-68-5 9-((2R,5S)-5-(H... CAS#:4294-16-0 N-Benzyladenosine CAS#:5987-73-5 9H-Purine,6-chl...
CAS#:20125-39-7 N6-(2-Phenyleth... CAS#:18945-36-3 9-[3,4-dihydrox...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray (Raja clavata) muscle.

J. Proteomics 128 , 458-68, (2015)

Thornback ray muscle hydrolysates (TRMHs) prepared by treatment with proteases from Bacillus subtilis A26 (TRMH-A26), Raja clavata crude alkaline protease extract (TRMH-Crude), Alcalase (TRMH-Alcalase...

Solubilization of gliadins for use as a source of nitrogen in the selection of bacteria with gliadinase activity.

Food Chem. 168 , 439-44, (2014)

For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrog...

A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.

J. Chromatogr. A. 1360 , 240-7, (2014)

Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due ...

6-Oxopurine riboside

HXR

RIBOXINE

nosine

Ino

EINECS 200-390-4

9-β-δ-Ribofuranosylhypoxanthine

Hypoxanthine, 9-β-D-ribofuranosyl-

1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one

9-β-D-ribofuranosyl-Hypoxanthine

9-β-D-Ribofuranosylhypoxanthine

Inosie

9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one

INO 495

hypoxanthine

Oxiamin

9-b-D-Ribofuranosylhypoxanthine

Atorel

MFCD00066770

6H-Purin-6-one, 1,9-dihydro-9-β-D-ribofuranosyl-

9β-D-Ribofuranosylhypoxanthine

6-oxy-purine riboside

9H-Purin-6-ol, 9-β-D-ribofuranosyl-

9-β-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one

9-b-D-ribofuranosyl-Hypoxanthine

Inosine

9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one

T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q &&β-D-Ribo Form

Inosine (8CI,9CI)

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China
Product Name: Inosine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Inosine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
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Delivery: Inquiry
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Inosine

Use of Inosine

Names

Inosine Biological Activity

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MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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