2-Aminoquinoline

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Names

[ CAS No. ]:
580-22-3

[ Name ]:
2-Aminoquinoline

[Synonym ]:
MFCD00038079
2(1H)-Quinolinimine
2-Aminoquindine
EINECS 209-458-8
2-Quinolinamine
iminoquinoline
quinolin-2-amine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
304.9±15.0 °C at 760 mmHg

[ Melting Point ]:
125 °C

[ Molecular Formula ]:
C9H8N2

[ Molecular Weight ]:
144.17

[ Flash Point ]:
163.6±7.6 °C

[ Exact Mass ]:
144.068741

[ PSA ]:
38.91000

[ LogP ]:
1.73

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.708

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA9621800
CHEMICAL NAME :
Quinoline, 2-amino-
CAS REGISTRY NUMBER :
580-22-3
BEILSTEIN REFERENCE NO. :
0113163
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H8-N2
MOLECULAR WEIGHT :
144.19
WISWESSER LINE NOTATION :
T66 BNJ CZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
500 nmol/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 42,861,1978

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VA9621800

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chloroquinoline
  • 2-Bromoquinoline
  • 4-Chloro-8-ethylquinoline-3-carboxylic acid ethyl ester
  • Quinoline, 2-iodo-
  • benzyl-quinolin-2-yl-amine
  • quinoline 1-oxide
  • 4-Picoline
  • Z-1-cyano-2-(2'-nitrophenyl)ethene

DownStream

  • ethyl N-quinolin-2-ylcarbamate
  • 2-FLUOROQUINOLINE
  • 2-Quinolinamine,1-oxide
  • N-quinolin-8-ylbenzamide
  • 2-phenylimidazo[1,2-a]quinoline
  • imidazo[1,2-a]quinolin-1-amine
  • 3-(diethylamino)-6-(quinolin-2-ylhydrazinylidene)cyclohexa-2,4-dien-1-one
  • N-Quinolin-2-yl-acetamide

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and evaluation of the anti-nociceptive and anti-inflammatory activity of 4-aminoquinoline derivatives.

Bioorg. Med. Chem. 23 , 4390-6, (2015)

In this paper, we describe the synthesis and pharmacological evaluation of a series of 4-aminoquinolines. The compounds were characterised and tested in models of pain and inflammation, using the writ...


More Articles

Related Compounds

  • 2-Aminoquinoline
  • 2-aminoquinoline
  • 2-Aminoquinoline
  • 2-Aminoquinoline 1-oxide
  • 4-bromo-2-aminoquinoline
  • N-phenyl-2-aminoquinoline
  • N-(2-methyl-5-morpholin-4-ylsulfonylphenyl)-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide
  • 7-chloro-N-[5-(diethylsulfamoyl)-2-morpholin-4-ylphenyl]-1,3-benzodioxole-5-carboxamide
  • N-(4-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
  • 6-[[Hexahydro-4-[(4-methylphenyl)sulfonyl]-1H-1,4-diazepin-1-yl]carbonyl]-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one
  • [2-[[2-(2-Chloroanilino)-2-oxoethyl]-methylamino]-2-oxoethyl] 4-(4-hydroxyphenyl)benzoate
  • 2-(2-(Sec-butylamino)-2-oxoethoxy)benzamide
  • N-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-3-(trifluoromethyl)benzamide
  • 3-methoxy-4-[2-(2-methoxyanilino)-2-oxoethoxy]-N-(oxolan-2-ylmethyl)benzamide
  • 4,5,6-Trimethyl-2-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]sulfanylpyridine-3-carbonitrile
  • N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]-2-(N-methyl-2-phenylethenesulfonamido)acetamide
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