4-Amino-1-naphthonitrile

Suppliers

Names

[ CAS No. ]:
58728-64-6

[ Name ]:
4-Amino-1-naphthonitrile

[Synonym ]:
MFCD00004022
1-cyano-4-aminonaphthalene
1-amino-4-cyanonaphthalene
4-cyano-1-aminonaphthalene
4-Amino-1-naphthonitrile
4-amino-1-naphthalene-carbonitrile
4-cyano-1-naphthylamine
1-Naphthalenecarbonitrile, 4-amino-
1-NAPHTHALENECARBONITRILE,4-AMINO
EINECS 261-412-6

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
392.4±25.0 °C at 760 mmHg

[ Melting Point ]:
174.5-176.5ºC(lit.)

[ Molecular Formula ]:
C11H8N2

[ Molecular Weight ]:
168.195

[ Flash Point ]:
191.1±23.2 °C

[ Exact Mass ]:
168.068741

[ PSA ]:
49.81000

[ LogP ]:
2.30

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.687

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ1865000
CHEMICAL NAME :
1-Naphthalenecarbonitrile, 4-amino-
CAS REGISTRY NUMBER :
58728-64-6
BEILSTEIN REFERENCE NO. :
2937292
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H8-N2
MOLECULAR WEIGHT :
168.21
WISWESSER LINE NOTATION :
L66J BZ ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05168

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21

[ Safety Phrases ]:
S23

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2926909090

Precursor & DownStream

Precursor

  • 4-acetylamino-[1]naphthonitrile
  • 1,4-Naphthalenedicarbonitrile
  • 1-Cyano-4-nitronaphthalene

DownStream

  • 4-Chloro-1-naphthoic acid
  • 4-Bromonaphthalene-1-carbonitrile
  • 1-Cyano-4-nitronaphthalene
  • 4-iodonaphthalene-1-carbonitrile
  • 4-Amino-1-naphthoic acid
  • 4-(phenylmethoxycarbonylamino)naphthalene-1-carboxylic acid
  • Ethyl 4-amino-1-naphthoate
  • 4-isocyanatonaphthalene-1-carbonitrile
  • 4-piperidin-1-ylnaphthalene-1-carbonitrile

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.

Bioorg. Med. Chem. 7(12) , 3011-24, (1999)

Cysteine farnesylation at the carboxylate terminal tetrapeptide CAAX of Ras protein is catalyzed by farnesyltransferase. This lipid modification is necessary for regulatory function of both normal and...


More Articles

Related Compounds

  • 4-amino-3-nitro-1-naphthonitrile
  • 4-amino-2-methyl-[1]naphthonitrile
  • 4-amino-1-methyl-3-nitroquinolin-2-one
  • 4-amino-1-[(2R,3R,4S,5S)-3-hydroxy-4,5-bis(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 4-Amino-1-methyl-3-N-propyprzole-5-carboxamide
  • [4-amino-1-(oxolan-3-yl)pyrazolo[3,4-b]pyridin-3-yl]methanol