4-Amino-1-naphthonitrile
4-Amino-1-naphthonitrile structure
|
Common Name | 4-Amino-1-naphthonitrile | ||
|---|---|---|---|---|
| CAS Number | 58728-64-6 | Molecular Weight | 168.195 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 392.4±25.0 °C at 760 mmHg | |
| Molecular Formula | C11H8N2 | Melting Point | 174.5-176.5ºC(lit.) | |
| MSDS | N/A | Flash Point | 191.1±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.
Bioorg. Med. Chem. 7(12) , 3011-24, (1999) Cysteine farnesylation at the carboxylate terminal tetrapeptide CAAX of Ras protein is catalyzed by farnesyltransferase. This lipid modification is necessary for regulatory function of both normal and oncogenic Ras. The high frequency of Ras mutation in human... |
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