Trichostatin A

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Names

[ CAS No. ]:
58880-19-6

[ Name ]:
Trichostatin A

[Synonym ]:
Antibiotic A-300
2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
(R)-Trichostatin A
2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI)
TSA
2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-
Trichostatin A
7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Melting Point ]:
141-143ºC

[ Molecular Formula ]:
C17H22N2O3

[ Molecular Weight ]:
302.368

[ Exact Mass ]:
302.163055

[ PSA ]:
69.64000

[ LogP ]:
2.77

[ Index of Refraction ]:
1.578

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MI5215000
CHEMICAL NAME :
2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7- oxo-
CAS REGISTRY NUMBER :
58880-19-6
LAST UPDATED :
198912
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H22-N2-O3
MOLECULAR WEIGHT :
302.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - rat Embryo
DOSE/DURATION :
100 ug/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 177,122,1988

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P302 + P352 + P312-P304 + P340 + P312-P333 + P313

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NA 1993 / PGIII

[ WGK Germany ]:
3

[ RTECS ]:
MI5215000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • O-(2-methoxypropyl)-(S)-trichostatin A
  • (R)-trichostatic acid
  • ethyl (2E,4E,6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dim ethyl-hepta-2,4-dienoate
  • p-Dimethylaminobenzaldehyde
  • (2S)-3-(4-(dimethylamino)phenyl)-3-((2-methoxypropan-2-yl)oxy)-2-methylpropanal
  • 3-t-butyldimethylsilyloxy-1-(4'-N,N-dimethylaminophenyl)-2-(S)-methyl-1-propanol
  • 3-(4'-N,N-dimethylaminophenyl)-3-(2-methoxypropyloxy)-2-(R)-methyl-1-propanol
  • 2,4-(R)-dimethyl-5-(4'-N,N-dimethylaminophenyl)-5-(2-methoxypropyloxy)-2-penten-1-ol
  • trichostatic acid

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • Trichostatin A
  • Inhibitor of Trichostatin A 1
  • O-(2-methoxypropyl)-(S)-trichostatin A
  • lactococcin A
  • maquiroside A
  • Poly(A)-poly(dA)
  • 4-(Methylthio)thieno[3,2-d]pyrimidine-6-carbaldehyde
  • 7-(2-Aminoethylamino)-4-(2-bromo-4-fluorophenoxy)-6-methoxyquinazoline
  • n-Diphenylmethylene-6-hydroxy-7-methoxyquinazolin-4-amine
  • 7-Carboxy-6-methoxy-4-(2,4,6-trimethoxybenzylamino)quinazoline
  • Thieno[2,3-c]pyridin-4-amine
  • 4-Amino-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline
  • 4-(2-Fluorophenyl)-1-methylpiperidine-4-carboxylic acid
  • (R)-2-(3-Bromophenyl)morpholine
  • 5-(3-Iodopropyl)-3-methyl-1,2-oxazole
  • Benzenemethanesulfonamide,4-[[(3,4-dichloro-1h-indol-7-yl)amino]sulfonyl]-
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