Ethyl 4-chloro-2-Methylthio-5-pyriMidinecarboxylate

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Names

[ CAS No. ]:
5909-24-0

[ Name ]:
Ethyl 4-chloro-2-Methylthio-5-pyriMidinecarboxylate

[Synonym ]:
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
EINECS 227-619-0
Ethyl 4-chloro-2-(methylsulfanyl)-5-pyrimidinecarboxylate
ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate
Ethyl 4-chloro-2-(methylthio)-5-pyrimidinecarboxylate
MFCD00006085
4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester
4-chloro-5-carbethoxy-2-methylthiopyrimidine
5-Pyrimidinecarboxylic acid, 4-chloro-2-(methylthio)-, ethyl ester
Ethyl-4-chlor-2-(methylsulfanyl)pyrimidin-5-carboxylat
5-Pyrimidinecarboxylic acid, 4-chloro-2- (methylthio)-, ethyl ester
ethyl 4-chloro-2-methylsulfanylpyrimidine-5-carboxylate
ethyl4-chloro-2-(methylthio)pyrimidine-5-carboxylate

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
335.7±22.0 °C at 760 mmHg

[ Melting Point ]:
60-63 °C(lit.)

[ Molecular Formula ]:
C8H9ClN2O2S

[ Molecular Weight ]:
232.687

[ Flash Point ]:
156.8±22.3 °C

[ Exact Mass ]:
232.007324

[ PSA ]:
77.38000

[ LogP ]:
2.55

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.568

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate
  • Diethyl ethoxymethylenemalonate

DownStream

  • ETHYL 2-(METHYLTHIO)-4-(PHENYLAMINO)PYRIMIDINE-5-CARBOXYLATE
  • 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
  • 4-(3-Chloro-4-Methoxy-benzylaMino) -2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester
  • ethyl 2-methylsulfonylpyrimidine-5-carboxylate
  • N-[6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-ylidene]acetamide
  • ethyl 4-(cyclopentylamino)-2-methylsulfanylpyrimidine-5-carboxylate
  • 8-cyclopentyl-2-methylsulfinylpyrido[2,3-d]pyrimidin-7-one
  • (4-(ethylamino)-2-(Methylthio)pyrimidin-5-yl)Methanol
  • 6-(2,6-Dichlorophenyl)-8-methyl-2-methylsulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one
  • ETHYL 4-(ETHYLAMINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.

Bioorg. Med. Chem. Lett. 18(7) , 2355-61, (2008)

A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the...


More Articles

Related Compounds

  • 2-(2,3-dihydro-1H-inden-5-yl)-2-methylpropanenitrile
  • 3-Azido-1,1,1,2,2-pentafluoropropane
  • 5-(3-methoxyphenyl)-1-methyl-1H-pyrazole-4-carboxylic acid
  • 3-Methyl-4-(propan-2-yloxy)benzene-1-sulfonyl fluoride
  • N-(3-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propyl)pivalamide
  • 3-fluoro-N-(3-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propyl)benzamide
  • N-(3-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propyl)-2,5-dimethylfuran-3-carboxamide
  • N-(3-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propyl)-4-methylthiophene-2-carboxamide
  • 2-cyclohexyl-N-(3-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propyl)acetamide
  • Tert-butyl 4-bromo-3-(trifluoromethyl)benzoate
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