(Chloromethyl)(trimethoxy)silane

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Names

[ CAS No. ]:
5926-26-1

[ Name ]:
(Chloromethyl)(trimethoxy)silane

[Synonym ]:
G1-SI-O1&O1&O1
Chloromethyltrimethoxysilane
Silane, (chloromethyl)trimethoxy-
(Chloromethyl)(trimethoxy)silane
MFCD00468107
chloromethyl(trimethoxy)silane
Chloromethyl Trimethoxysilane

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
132.2±13.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H11ClO3Si

[ Molecular Weight ]:
170.667

[ Flash Point ]:
30.1±12.0 °C

[ Exact Mass ]:
170.016602

[ PSA ]:
27.69000

[ LogP ]:
0.37

[ Vapour Pressure ]:
11.0±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.405

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VV2625000
CHEMICAL NAME :
Silane, chloromethyl-trimethoxy-
CAS REGISTRY NUMBER :
5926-26-1
LAST UPDATED :
199806
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C4-H11-Cl-O3-Si
MOLECULAR WEIGHT :
170.69
WISWESSER LINE NOTATION :
G1-SI-O1&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1222,1986
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1222,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1222,1986
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1222,1986

Safety Information

[ Symbol ]:

GHS02

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225

[ Precautionary Statements ]:
P210

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F

[ Risk Phrases ]:
11

[ Safety Phrases ]:
S16-S29-S33

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Trimethyl orthoformate
  • Methanol
  • 1,1,1-Trimethoxyethane
  • Trichloro(chloromethyl)silane

DownStream

  • trimethoxysilylmethyl 2-(2-methylphenoxy)acetate
  • chloromethylsilatrane
  • Methoxymethyl TrimethoxySilane
  • Stannane,chlorotriethyl-
  • N-[(Trimethoxysilyl)methyl]aniline
  • (Trimethoxysilyl)methyl methacrylate
  • N-butyl-N-(trimethoxysilylmethyl)butan-1-amine
  • (Trimethoxysilyl)methanethiol
  • N-Methyl-1-(triMethoxysilyl)Methanamine

Articles

Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia.

ACS Nano 9 , 10778-89, (2015)

We have optimized mesoporous silica nanoparticles (MSNs) functionalized with pH-sensitive nanovalves for the delivery of the broad spectrum fluoroquinolone moxifloxacin (MXF) and demonstrated its effi...

Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.

J. Am. Chem. Soc. 132(36) , 12690-7, (2010)

Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in or...

Space-confined click reactions in hierarchically organized silica monoliths. Keppeler M and Hüsing N

New J. Chem. 35(3) , 681-690, (2011)


More Articles

Related Compounds

  • Chloromethyl silane
  • isothiocyanato-trimethoxy-silane
  • fluoromethyl(trimethoxy)silane
  • Decyl(trimethoxy)silane
  • heptadecyl(trimethoxy)silane
  • Isobutyl(trimethoxy)silane
  • (2R)-1-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)propan-2-ol
  • (2S)-1-(4-chlorothiophen-2-yl)propan-2-amine
  • tert-butyl N-[3-methyl-3-(methylamino)butyl]carbamate
  • [1-(3,5-Dichlorophenyl)-2,2-dimethylcyclopropyl]methanamine
  • 2-(4-{[(Tert-butoxy)carbonyl]amino}-2-chlorophenyl)butanedioic acid
  • 1-(2-Methylbut-3-yn-2-yl)-4-(propan-2-yloxy)benzene
  • 2-(3,3-Dimethylcyclopentyl)prop-2-enoic acid
  • 3-[(5-Methylpyridin-2-yl)methyl]pyrrolidin-3-ol
  • 3-(Aminomethyl)-3-(5-methoxypyridin-2-yl)cyclobutan-1-ol
  • (2R)-1-(2,3-dihydro-1,4-benzodioxin-2-yl)propan-2-amine
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