7-Hydroxymethotrexate

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Names

[ CAS No. ]:
5939-37-7

[ Name ]:
7-Hydroxymethotrexate

[Synonym ]:
7-hydroxy methotrexate

Chemical & Physical Properties

[ Density]:
1.68g/cm3

[ Melting Point ]:
230ºC dec.

[ Molecular Formula ]:
C20H22N8O6

[ Molecular Weight ]:
470.43900

[ Exact Mass ]:
470.16600

[ PSA ]:
230.77000

[ LogP ]:
1.52730

[ Index of Refraction ]:
1.76

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA1000000
CHEMICAL NAME :
L-Glutamic acid, N-(4-(((2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)me thyl)methylamino) benzoyl)-
CAS REGISTRY NUMBER :
5939-37-7
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H22-N8-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978- Volume(issue)/page/year: 37,415,1996

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methotrexate dimethyl ester
  • Amethopterin

DownStream

Related Compounds

  • 7-Hydroxymethotrexate-d3
  • (7-BENZYL-7-AZABICYCLO[2.2.1]HEPTAN-1-YL)METHANAMINE
  • 7-Hydroxymethyl-3-oxa-bicyclo[3.3.1]nonan-9-one
  • 7-methylguanosine-5'-monophosphate
  • 7-Benzyloxymethylnorbornen-5-on
  • (2s,5s)-5-(hydroxymethyl)-1-methyl-9-octyl-2-(propan-2-yl)-1,2,4,5,6,8-hexahydro-3h-[1,4]diazonino[7,6,5-cd]indol-3-one