L-Tyrosine
Suppliers
Names
[ CAS No. ]:
60-18-4
[ Name ]:
L-Tyrosine
[Synonym ]:
L-tyrosine zwitterion
hydrogen L-tyrosinate
MEVINOLIN
LOVALIP
a-Amino-p-hydroxyhydrocinnamic Acid
L-Phenylalanine, 4-hydroxy-
LOVASTIN
MEVACOR
H-Tyr-OH
Tyrosine
MFCD00002606
L-Tyr
Rovacor
Tyr
(S)-(-)-Tyrosine
Sivlor
L-Tyrosine
(S)-a-Amino-4-hydroxybenzenepropanoic acid
Tyrosine, L-
b-(p-Hydroxyphenyl)alanine
mevlor
Benzenepropanoic acid, α-amino-4-hydroxy-, (S)-
Tyrosinum [Latin]
(S)-a-amino-4-hydroxy-Benzenepropanoic acid
(S)-tyrosine
(S)-α-amino-4-hydroxy-Benzenepropanoic acid
EINECS 200-460-4
msd803
Paschol
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
385.2±32.0 °C at 760 mmHg
[ Melting Point ]:
>300 °C (dec.)(lit.)
[ Molecular Formula ]:
C9H11NO3
[ Molecular Weight ]:
181.189
[ Flash Point ]:
186.7±25.1 °C
[ Exact Mass ]:
181.073898
[ PSA ]:
83.55000
[ LogP ]:
0.38
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.614
[ Water Solubility ]:
0.45 g/L (25 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP2275600
- CHEMICAL NAME :
- Tyrosine, L-
- CAS REGISTRY NUMBER :
- 60-18-4
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C9-H11-N-O3
- MOLECULAR WEIGHT :
- 181.21
- WISWESSER LINE NOTATION :
- QVYZ1R DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/2W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20750 mg/kg
- SEX/DURATION :
- female 15-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 gm/kg
- SEX/DURATION :
- female 11-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3500 mg/kg
- SEX/DURATION :
- female 15-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 29-31 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81869 No. of Facilities: 133 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1421 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81869 No. of Facilities: 275 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 14731 (estimated) No. of Female Employees: 12371 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YP2275600
[ HS Code ]:
29225000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
J. Chromatogr. A. 1361 , 265-76, (2014)
This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...
Antonie van Leeuwenhoek 107(4) , 1001-8, (2015)
A yellow-pigmented bacterium, designated strain GZGR-4(T), was isolated from the root of Hylomecon japonica (Thunb.) Prantl et Kündig collected from Taibai Mountain in Shaanxi Province, north-west Chi...
Antonie van Leeuwenhoek 108 , 695-701, (2015)
A yellowish colored, Gram-staining negative, strictly aerobic, motile, rod-shaped bacterium, designated THG-SQE7(T), was isolated from reed pond water in Shangqiu, PR China. Comparative 16S rRNA gene ...