Gestodene

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Names

[ CAS No. ]:
60282-87-3

[ Name ]:
Gestodene

[Synonym ]:
(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one
SH B 331
GESTOGENE
(8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
SH B 33
Femodene
EINECS 262-145-8
Gestodene
GESTODONE
17a-Ethynyl-13-ethyl-17b-hydroxy-4,15-gonadien-3-one
SHG 415 G
17a-Ethynyl-17b-hydroxy-18-methyl-4,15-estradien-3-one
Gynovin
MFCD00867858

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
462.7±45.0 °C at 760 mmHg

[ Melting Point ]:
190-192°C

[ Molecular Formula ]:
C21H26O2

[ Molecular Weight ]:
310.430

[ Flash Point ]:
196.9±21.3 °C

[ Exact Mass ]:
310.193268

[ PSA ]:
37.30000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JF7956000
CHEMICAL NAME :
18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)-
CAS REGISTRY NUMBER :
60282-87-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H26-O2
MOLECULAR WEIGHT :
310.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
12 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,459,1985

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
62

[ Safety Phrases ]:
S22-S36/37

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-ethoxy-18-methyl-estra-3,5,15-trien-17-one
  • Bromo(ethynyl)magnesium
  • Bromoethane
  • Acetylene
  • 17α-Ethinyl-3,3-ethylendithio-18-methyl-4,15-estradien-17β-ol
  • D-Ethylgonendione
  • 15ALPHA-HYDROXY-18-METHYL-ESTRA-4-ENE-3,18-DIONE
  • 13-ETHYL-18,19-DINORPREGNA-3,17-DIONE-4-ENE-15-ACETOXYL
  • 3,3-Ethylendithio-18-methyl-4,15-estradien-17-on
  • 3,3-Ethylendithio-15α-hydroxy-18-methyl-4-estren-17-on

DownStream

Articles

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Gynecol. Endocrinol. 28(8) , 606-10, (2012)

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Related Compounds

  • Methyl Gestodene
  • Gestodene InterMediates
  • Gestodene Sulfate Sodium Salt
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  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-Ethoxy-2-(oxan-4-yl)acetonitrile
  • 1-Cyclopropyl-3-(3-fluorophenyl)propane-1,3-dione
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • Ethyl {[1-(pyridin-3-yl)ethyl]carbamoyl}formate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde