Thymine-beta-D-arabinofuranoside
Suppliers
Names
[ CAS No. ]:
605-23-2
[ Name ]:
Thymine-beta-D-arabinofuranoside
[Synonym ]:
Thymine arabinofuranoside
Thymine, 1-β-D-arabinofuranosyl-
1-(β-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
spongothymidine
thymine arabinoside
ARABINOFURANOSYL-5-METHYLURACIL
EINECS 210-083-7
MFCD00065474
1-(β-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidindion
5-Methyl-1-pentofuranosyl-2,4(1H,3H)-pyrimidinedione
ARA-T
5-Methyl-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-5-methyl-
1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-5-méthyl-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-pentofuranosyl-
1-B-D-Arabinofuranosylthymine
spongothymidin
Arabinofuranosylthymine
1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Thymine 1-beta-D-arabinofuranoside
1-β-D-Arabinofuranosylthymine
arabinosylthymine
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Molecular Formula ]:
C10H14N2O6
[ Molecular Weight ]:
258.23
[ Exact Mass ]:
258.085175
[ PSA ]:
124.78000
[ LogP ]:
-1.02
[ Index of Refraction ]:
1.619
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XP2100200
- CHEMICAL NAME :
- Thymine, 1-beta-D-arabinofuranosyl-
- CAS REGISTRY NUMBER :
- 605-23-2
- BEILSTEIN REFERENCE NO. :
- 0090166
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H14-N2-O6
- MOLECULAR WEIGHT :
- 258.26
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 7100 ug/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 23,141,1978
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
XP2100200
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 1345-54, (2015)
Liposomal drug delivery vehicles are promising nanomedicine tools for bringing cytotoxic drugs to cancerous tissues selectively. However, the triggered cargo release from liposomes in response to a ta...
Sci. Transl. Med. 7 , 315ra188, (2015)
Targeted drug delivery with antibody-drug conjugates such as the HER2-directed ado-trastuzumab emtansine (T-DM1) has emerged as a powerful strategy for cancer therapy. We show that T-DM1 is particular...
Invest. Ophthalmol. Vis. Sci. 56 , 4117-24, (2015)
This study aimed to develop a greater understanding of the mechanisms underlying acute corneal allograft rejection by identifying differentially expressed tear proteins at defined stages and discoveri...