Alaproclate HCl

Names

[ CAS No. ]:
60719-83-7

[ Name ]:
Alaproclate HCl

[Synonym ]:
[1-(4-chlorophenyl)-2-methylpropan-2-yl] 2-aminopropanoate,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
324.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₉Cl₂NO₂

[ Molecular Weight ]:
292.20

[ Flash Point ]:
150.2ºC

[ Exact Mass ]:
291.07900

[ PSA ]:
52.32000

[ LogP ]:
4.05380

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4397300

CHEMICAL NAME :: DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 60719-83-7

LAST UPDATED :: 199403

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H18-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 292.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 901 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
AY4397300

Articles

The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats.

Pharmacol. Biochem. Behav. 39(1) , 25-9, (1991)

In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cu...

The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.

J. Neural Transm. Park. Dis. Dement. Sect. 4(1) , 43-52, (1992)

The present study investigates the effects of a serotonin (5-HT) reuptake inhibitor, alaproclate, on water maze cued navigation performance in serotonin depleted and control rats. Treatment with p-chl...

Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.

Psychopharmacology 103(4) , 567-70, (1991)

The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alapro...