Alaproclate HCl
Alaproclate HCl structure
|
Common Name | Alaproclate HCl | ||
|---|---|---|---|---|
| CAS Number | 60719-83-7 | Molecular Weight | 292.20 | |
| Density | N/A | Boiling Point | 324.8ºC at 760 mmHg | |
| Molecular Formula | C13H19Cl2NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 150.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Alaproclate HClAlaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2]. |
Summary: Alaproclate hydrochloride (Alaproclate HCl) is a selective serotonin reuptake inhibitor (SSRI). Its CAS number is 60719-83-7, with a molecular formula of C13H19Cl2NO2 and a molecular weight of 292.20. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Alaproclate hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2]. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 324.8ºC at 760 mmHg |
|---|---|
| Molecular Formula | C13H19Cl2NO2 |
| Molecular Weight | 292.20 |
| Flash Point | 150.2ºC |
| Exact Mass | 291.07900 |
| PSA | 52.32000 |
| LogP | 4.05380 |
| InChIKey | OPAKSOWFKIUFNP-UHFFFAOYSA-N |
| SMILES | CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1.Cl |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22 |
| RIDADR | UN 2811 6.1/PG 3 |
| RTECS | AY4397300 |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats.
Pharmacol. Biochem. Behav. 39(1) , 25-9, (1991) In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cu... |
|
|
The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.
J. Neural Transm. Park. Dis. Dement. Sect. 4(1) , 43-52, (1992) The present study investigates the effects of a serotonin (5-HT) reuptake inhibitor, alaproclate, on water maze cued navigation performance in serotonin depleted and control rats. Treatment with p-chl... |
|
|
Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.
Psychopharmacology 103(4) , 567-70, (1991) The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alapro... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
|
|
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
|
|
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| [1-(4-chlorophenyl)-2-methylpropan-2-yl] 2-aminopropanoate,hydrochloride |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does Alaproclate hydrochloride have? |
| A: English synonyms of Alaproclate hydrochloride: [1-(4-chlorophenyl)-2-methylpropan-2-yl] 2-aminopropanoate,hydrochloride. |
| Q: What is the molecular formula of Alaproclate hydrochloride? |
| A: Molecular formula of Alaproclate hydrochloride is C13H19Cl2NO2. |
| Q: What is the English name of Alaproclate hydrochloride? |
| A: The English name of Alaproclate hydrochloride is Alaproclate hydrochloride. |
| Q: What is the boiling point of Alaproclate hydrochloride? |
| A: Boiling point of Alaproclate hydrochloride is 324.8ºC at 760 mmHg. |
| Q: What is the InChIKey of Alaproclate hydrochloride? |
| A: InChIKey of Alaproclate hydrochloride is OPAKSOWFKIUFNP-UHFFFAOYSA-N. |
| Q: What is the CAS number of Alaproclate hydrochloride? |
| A: CAS number of Alaproclate hydrochloride is 60719-83-7. |
| Q: What is the molecular weight of Alaproclate hydrochloride? |
| A: Molecular weight of Alaproclate hydrochloride is 292.20. |
| Q: What are the uses of Alaproclate hydrochloride? |
| A: Main uses of Alaproclate hydrochloride: Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2]. |
| Q: What is the SMILES notation of Alaproclate hydrochloride? |
| A: SMILES notation of Alaproclate hydrochloride is CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1.Cl. |
| Q: What is the polar surface area (PSA) of Alaproclate hydrochloride? |
| A: Polar surface area (PSA) of Alaproclate hydrochloride is 52.32000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |