Prostratin

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Names

[ CAS No. ]:
60857-08-1

[ Name ]:
Prostratin

[Synonym ]:
(1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
13-O-Acetyl-12-deoxyphorbol
12-Deoxyphorbol-13-acetate
Stillingia Facto
5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)-
12-Deoxyphorbol 13-Acetate,dPAc
13-O-Acetylphorbol
Stillingia factor S7
SA 101A
prostratin
12-deoxyphorbal-13-acetate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
550.5±50.0 °C at 760 mmHg

[ Melting Point ]:
216-219℃

[ Molecular Formula ]:
C22H30O6

[ Molecular Weight ]:
390.470

[ Flash Point ]:
188.7±23.6 °C

[ Exact Mass ]:
390.204254

[ PSA ]:
104.06000

[ LogP ]:
1.84

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
?20°C

[ Water Solubility ]:
Soluble in DMSO at 30mg/ml

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (3aR,3bS,6aR,9aS,9bR,10R,11aS)-6a,9b-dihydroxy-5-(hydroxymethyl)-3,3,8,10-tetramethyl-7-oxo-3,3a,3b,6,6a,7,9a,9b,10,11-decahydro-11aH-azuleno[5,4-e]indazol-11a-yl acetate
  • 4β,9α,20-trihydroxy-13,15-seco-1,6,15-tigliatriene-3,13-dione

DownStream

Articles

IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency.

Virology 481 , 142-50, (2015)

IFI44 is an interferon-alfa inducible protein, and is associated with infection of several viruses. However, IFI44 elicits minimal antiviral effects on these viruses, and its exact role is still unkno...

Sulfonation pathway inhibitors block reactivation of latent HIV-1.

Virology 471-473 , 1-12, (2014)

Long-lived pools of latently infected cells are a significant barrier to the development of a cure for HIV-1 infection. A better understanding of the mechanisms of reactivation from latency is needed ...

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

PLoS ONE 4(6) , e6093, (2009)

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus...


More Articles

Related Compounds

  • prostratin C
  • prostratin A
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-(2,2-Dimethylpropanoyl)benzene-1-sulfonamide
  • 7-(Trifluoromethyl)-1-naphthaldehyde
  • 2-(2-Amino-5-methyl-4-(trifluoromethoxy)pyridin-3-yl)acetic acid
  • 2-(Difluoromethyl)-5-iodo-3-methylpyridine-4-methanol